Anti-Tyro3 Antibody

Dtk/TYRO3 antibody

Boster Bio Anti-Tyro3 Antibody (Catalog # M00913-1). Tested in WB application(s). This antibody reacts with Mouse.

Product Info Summary

SKU: M00913-1
Size: 80 µl
Reactive Species: Mouse
Host: Mouse
Application: WB

Product Name

Anti-Tyro3 Antibody

View all Dtk/TYRO3 Antibodies

SKU/Catalog Number

M00913-1

Size

80 µl

Description

Boster Bio Anti-Tyro3 Antibody (Catalog # M00913-1). Tested in WB application(s). This antibody reacts with Mouse.

Storage & Handling

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Cite This Product

Anti-Tyro3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00913-1)

Host

Mouse

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Clonality

Monoclonal

Clone Number

1444CT895.86.31

Isotype

IgG1,k

Immunogen

This Tyro3 antibody is generated from a mouse immunized with a recombinant protein.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M00913-1 is reactive to TYRO3 in Mouse

Applications

M00913-1 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

96.905kDa

Background of Dtk/TYRO3

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:2000

Validation Images & Assay Conditions

Gene/Protein Information For TYRO3 (Source: Uniprot.org, NCBI)

Gene Name

TYRO3

Full Name

Tyrosine-protein kinase receptor TYRO3

Weight

96.905kDa

Superfamily

protein kinase superfamily

Alternative Names

Brt; BYK; Dtk; EC 2.7.10; EC 2.7.10.1; FLJ16467; Rse; Sky; Tif; TYRO3 protein tyrosine kinase; Tyro3; Tyrosine-protein kinase byk; Tyrosine-protein kinase DTK; tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY TYRO3 BYK, Dtk, Etk-2, RSE, Rek, Sky, Tif TYRO3 protein tyrosine kinase tyrosine-protein kinase receptor TYRO3|tyrosine-protein kinase DTK|tyrosine-protein kinase RSE|tyrosine-protein kinase SKY|tyrosine-protein kinase TIF|tyrosine-protein kinase byk

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on TYRO3, check out the TYRO3 Infographic

TYRO3 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for TYRO3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
M00913-1-80ul

80 µl

$298
M00913-1-400ul

400 µl

$460

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M00913-1
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*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
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