Anti-UBR1 Antibody

Product Name

Anti-UBR1 Antibody

View all Ubr1 Antibodies

SKU/Catalog Number

A03250

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-UBR1 Antibody (Catalog # A03250). Tested in WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-UBR1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03250)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human UBR1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A03250 is reactive to Ubr1 in Human, Mouse

Applications

A03250 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

200.24kDa

Background of Ubr1

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.

Kwak K.S., Cancer Res. 64:8193-8198(2004).
Dgany O., Am. J. Hum. Genet. 71:1467-1474(2002).
Ota T., Nat. Genet. 36:40-45(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Validation Images & Assay Conditions

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Western blot analysis of extracts from Jurkat cells and HepG2 cells, using UBR1 antibody A03250.

Gene/Protein Information For Ubr1 (Source: Uniprot.org, NCBI)

Alternative Names

E3 ubiquitin-protein ligase UBR1; E3a ligase; EC 6.3.2.-; JBS; MGC142065; MGC142067; N-recognin-1; ubiquitin ligase E3 alpha-I; ubiquitin protein ligase E3 component n-recognin 1; ubiquitin-protein ligase E3-alpha; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I Ubr1|AI504731|ubiquitin protein ligase E3 component n-recognin 1|E3 ubiquitin-protein ligase UBR1|E3 alpha|N-recognin-1|RING-type E3 ubiquitin transferase UBR1|ubiquitin-protein ligase E3-alpha-1|ubiquitin-protein ligase E3-alpha-I|ubiquitin-protein ligase e3 componen n-recognin

For more info on Ubr1, check out the Ubr1 Infographic

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In this infographic, you will see the following information for Ubr1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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