Anti-VEGFR3 Antibody

VEGFR3/Flt-4 antibody

Boster Bio Anti-VEGFR3 Antibody catalog # M01276-1. Tested in Flow Cytometry, IHC-P, WB applications. This antibody reacts with Human. Cited in 1 publication(s).

Product Info Summary

SKU: M01276-1
Size: 80 ul
Reactive Species: Human
Host: Mouse
Application: Flow Cytometry, IHC-P, WB

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Product Name

Anti-VEGFR3 Antibody

View all VEGFR3/Flt-4 Antibodies

SKU/Catalog Number

M01276-1

Size

80 ul

Description

Boster Bio Anti-VEGFR3 Antibody catalog # M01276-1. Tested in Flow Cytometry, IHC-P, WB applications. This antibody reacts with Human.

Storage & Handling

Cite This Product

Anti-VEGFR3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01276-1)

Host

Mouse

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

Clonality

Monoclonal

Isotype

IgG2a

Immunogen

Purified His-tagged VEGFR3 protein was used to produced this monoclonal antibody.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M01276-1 is reactive to FLT4 in Human

Applications

M01276-1 is guaranteed for Flow Cytometry, IHC-P, WB Boster Guarantee

Background of VEGFR3/Flt-4

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

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Validation Images & Assay Conditions

Gene/Protein Information For FLT4 (Source: Uniprot.org, NCBI)

Uniprot ID

P35916

Gene ID

2324

Gene Name

FLT4

Full Name

Vascular endothelial growth factor receptor 3

Weight

152.757kDa

Superfamily

protein kinase superfamily

Alternative Names

EC 2.7.10; EC 2.7.10.1; FLT4; Flt-4; fms-related tyrosine kinase 4; LMPH1A; PCLFLT41; soluble VEGFR3 variant 1; soluble VEGFR3 variant 2; soluble VEGFR3 variant 3; Tyrosine-protein kinase receptor FLT4; vascular endothelial growth factor receptor 3; VEGF R3; VEGFR3; VEGFR-3; VEGFR3Fms-like tyrosine kinase 4 FLT4 CHTD7, FLT-41, LMPH1A, LMPHM1, PCL, VEGFR-3, VEGFR3, FLT4 fms related receptor tyrosine kinase 4 vascular endothelial growth factor receptor 3|Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4|VEGF receptor-3|fms related tyrosine kinase 4|fms-like tyrosine kinase 4|primary congenital lymphedema|tyrosine-protein kinase receptor FLT4

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on FLT4, check out the FLT4 Infographic

FLT4 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for FLT4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected]

M01276-1 has been cited in 1 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Li,X.,Song,D.,Liu,H.,Wang,Z.,Ma,G.,Yu,M. ... Zeng,Y.(2021).Expression levels of VEGF‑C and VEGFR‑3 in renal cell carcinoma and their association with lymph node metastasis.Experimental and Therapeutic Medicine, 21,554.https://doi.org/10.3892/ etm.2021.9986
Species: Human
M01276-1 usage in article: APP:IHC, SAMPLE:RCC TISSUE, DILUTION:1:200

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SKU:M01276-1

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M01276-1
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$173.00

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