Anti-XIAP Antibody

XIAP antibody

Boster Bio Anti-XIAP Antibody catalog # PA1512. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. Cited in 4 publication(s).

Product Info Summary

SKU: PA1512
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC, WB

Product Name

Anti-XIAP Antibody

View all XIAP Antibodies

SKU/Catalog Number

PA1512

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-XIAP Antibody catalog # PA1512. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-XIAP Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1512)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human XIAP, different from the related mouse sequence by two amino acids.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1512 is reactive to XIAP in Human, Mouse, Rat

Applications

PA1512 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

57 kDa

Calculated molecular weight

56.685kDa

Background of XIAP

BIRC4, baculoviral IAP repeat-containing protein 4 is also known as XIAP (X-linked inhibitor of apoptosis protein). The BIRC4 gene comprises 6 exons. This gene is mapped to chromosome Xq25. This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse

Validation Images & Assay Conditions

Gene/Protein Information For XIAP (Source: Uniprot.org, NCBI)

Gene Name

XIAP

Full Name

E3 ubiquitin-protein ligase XIAP

Weight

56.685kDa

Superfamily

IAP family

Alternative Names

API3X-linked inhibitor of apoptosis protein; apoptosis inhibitor 3; baculoviral IAP repeat-containing 4; baculoviral IAP repeat-containing protein 4; BIRC4; BIRC4XLP2; E3 ubiquitin-protein ligase XIAP; EC 6.3.2.-; hIAP3; hIAP-3; hILP; IAP3; IAP-3; IAP-like protein; ILP; ILP1; Inhibitor of apoptosis protein 3; MIHA; XIAP; X-linked IAP; X-linked inhibitor of apoptosis XIAP API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis E3 ubiquitin-protein ligase XIAP|IAP-like protein 1|RING-type E3 ubiquitin transferase XIAP|X-linked IAP|X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase|baculoviral IAP repeat-containing protein 4|inhibitor of apoptosis protein 3

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on XIAP, check out the XIAP Infographic

XIAP infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for XIAP: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PA1512 has been cited in 4 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Wei H, Gao Z, Zheng L, Zhang C, Liu Z, Yang Y, Teng H, Hou L, Yin Y, Zou X0. Mar Drugs. 2017 Mar 16;15(3). pii: E77. doi: 10.3390/md15030077. Protective Effects of Fucoidan on Aβ25–35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced...

Chen Gg, Mao M, Qiu Lz, Liu Qm. Neural Regen Res. 2015 Mar;10(3):425-31. Doi: 10.4103/1673-5374.153691. Gene Transfection Mediated By Polyethyleneimine-Polyethylene Glycol Nanocarrier Prevents Cisplatin-Induced Spiral Ganglion Cell Damage.

Wu L, Xi Z, Guo R, Liu S, Yang S, Liu D, Dong S, Guo D. Avian Pathol. 2013 Feb;42(1):32-7. Doi: 10.1080/03079457.2012.757289. Exogenous Arc Down-Regulates Caspase-3 Expression And Inhibits Apoptosis Of Broiler Chicken Cardiomyocytes Exposed To Hyd...

Li G, Zhang S, Fang H, Yan B, Zhao Y, Feng L, Ma X, Ye X. Biochem Biophys Res Commun. 2013 May 17;434(4):809-14. Doi: 10.1016/J.Bbrc.2013.04.018. Epub 2013 Apr 20. Aspirin Overcomes Navitoclax-Resistance In Hepatocellular Carcinoma Cells Through S...

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Order DetailsPrice
PA1512

100μg

$370
PA1512-10ug

10μg sample (liquid)

$99
PA1512-Biotin

100 μg Biotin conjugated

$570
PA1512-Cy3

100 μg Cy3 conjugated

$570
PA1512-Dylight488

100 μg Dylight488 conjugated

$570
PA1512-Dylight550

100 μg Dylight550 conjugated

$570
PA1512-Dylight594

100 μg Dylight594 conjugated

$570
PA1512-FITC

100 μg FITC conjugated

$570
PA1512-HRP

100 μg HRP conjugated

$570
PA1512-APC

100 μg APC conjugated

$670
PA1512-PE

100 μg PE conjugated

$670
PA1512-carrier-free

Carrier Free

$370

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PA1512
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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