ABCA2 Antibodies

AND ABCA2 ELISA kits, ABCA2 Proteins

Many biological assays use antibodies to detect ABCA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABCA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABCA2 antibodies...

We validate the specificity of these antibodies to ABCA2 by testing them on tissues known to express ABCA2 positively and negatively. Browse below to find the ABCA2 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ABCA2 Infographic by Boster Bio

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ABCA2 Overview

Facts about ATP-binding cassette sub-family A member 2.

ABCA2 3D structure. Source: alphafold

ATP-binding cassette sub-family A member 2 (ABCA2)

Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.

Gene Information

Human
Gene Name:	ABCA2
Uniprot:	Q9BZC7
Entrez:	20

Family

Belongs to:

ABC transporter superfamily

Alternative Names

ABC2ATP-binding cassette, sub-family A, member 2; ATP-binding cassette 2; ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette, sub-family A (ABC1), member 2; EC 3.6.3; EC 3.6.3.41; KIAA1062; MGC129761

Molecular Weight

Mass (kDA):
269.833 kDA

Genomic Context


Human

Location:	9q34.3
Sequence:	9; NC_000009.12 (137007234..137028922, complement)

Tissue Specificity

Highly expressed in the brain, whereas lower levels of expression is observed in kidney and liver.

Subcellular Localizations

Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Forms discrete, punctate intracellular vesicles.

Diseases

Alzheimer's Disease
Carcinoma
Malignant Neoplasms
Neoplasms
Nervousness
Atherosclerosis
Neuroblastoma
Neurilemmoma
Acoustic Neuroma
Epithelial Ovarian Cancer
Liver Carcinoma
Malignant Paraganglionic Neoplasm

Liver Neoplasms
Neoplasm Metastasis
Glioma
Adenocarcinoma
Epilepsy
Prostatic Neoplasms
Senile Plaques

Pathways

Transport
Drug Resistance
Lipid Transport
Cholesterol Homeostasis
Myelination
Transmembrane Transport
Pathogenesis
Cholesterol Efflux
Lipid Homeostasis
Cholesterol Transport
Sterol Homeostasis
Sensitization
Localization

Reverse Cholesterol Transport
Cholesterol Import
Cell Adhesion
Gene Silencing
Brain Development
Cholesterol Esterification
Neurogenesis

PTMs

Cleavage

Phosphorylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCA2

References

PMID: 11178988 by Kaminski W.E., et al. Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages.

PMID: 11309290 by Vulevic B., et al. Cloning and characterization of human adenosine 5'-triphosphate- binding cassette, sub-family A, transporter 2.