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- Table of Contents
ABCA4 Antibodies
AND ABCA4 ELISA kits, ABCA4 Proteins
Many biological assays use antibodies to detect ABCA4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABCA4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABCA4 antibodies...
Designing a Western blot for ABCA4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ABCA4 Western Blot GuideABCA4 Infographic by Boster Bio
All ABCA4 Products
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ABCA4 Overview
Facts about Retinal-specific phospholipid-transporting ATPase ABCA4.
Retinal-specific phospholipid-transporting ATPase ABCA4 (ABCA4)
From the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 in the extracellular or intradiscal (pole ) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then moved to the retinal pigment epithelium (RPE) in which it is converted to 11-cis-retinal.
May play a role in photoresponse, removing ATR/NR-PE in the extracellular photoreceptor surfaces during bleach recovery. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ABCA4 |
| Uniprot: | P78363 |
| Entrez: | 24 |
Family
| Belongs to: |
|---|
| ABC transporter superfamily |
Alternative Names
ABC10; ABCRRMP; ARMD2DKFZp781N1972; ATP binding cassette transporter; ATP-binding cassette sub-family A member 4; ATP-binding cassette transporter, retinal-specific; ATP-binding cassette, sub-family A (ABC1), member 4; ATP-binding transporter, retina-specific; CORD3; EC 3.6.3; FFMFLJ17534; photoreceptor rim protein; retinal-specific ATP-binding cassette transporter; retina-specific ABC transporter; RIM ABC transporter; RIM protein; RmP; RP19; Stargardt disease protein; STGD; STGD1
Molecular Weight
Mass (kDA):
255.944 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p22.1 |
| Sequence: | 1; NC_000001.11 (93992834..94121148, complement) |
Tissue Specificity
Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells.
Subcellular Localizations
Membrane; Multi-pass membrane protein. Endoplasmic reticulum. Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor.
Diseases
- Age Related Macular Degeneration
- Stargardt's Disease
- Dystrophy
- Retinitis Pigmentosa
- Retinal Degeneration
- Retinal Diseases
- Retinal Dystrophies
- Hereditary Corneal Dystrophy
- Blind Vision
- Atrophy
- Abnormal Degeneration
- Visual Impairment
Pathways
- Transport
- Pathogenesis
- Lipid Transport
- Localization
- Regeneration
- Cell Death
- Phagocytosis
- Lipid Homeostasis
- Phototransduction
- Cholesterol Transport
- Secretion
- Keratinization
- Cholesterol Efflux
PTMs
- Glycosylation
- Phosphorylation
Research Areas
- ABC Transporters
- Lipid and Metabolism
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCA4
bosterbio.com/bosterbio-gene-info-cards/ABCA4
References
PMID: 9054934 by Allikmets R., et al. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy.
PMID: 9202155 by Azarian S.M., et al. The photoreceptor rim protein is an ABC transporter encoded by the gene for recessive Stargardt's disease (ABCR).