ACSL3 Antibodies

Long-chain-fatty-acid--CoA ligase 3 (ACSL3)

Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity).

Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism.

Gene Information

Human
Gene Name:	ACSL3
Uniprot:	O95573
Entrez:	2181

Family

Belongs to:
ATP-dependent AMP-binding enzyme family

Alternative Names

ACS3EC 6.2.1.3; acyl-CoA synthetase long-chain family member 3; FACL3lignoceroyl-CoA synthase; fatty-acid-Coenzyme A ligase, long-chain 3; LACS 3; LACS3; Long-chain acyl-CoA synthetase 3; long-chain-fatty-acid--CoA ligase 3; PRO2194

Molecular Weight

Mass (kDA):
80.42 kDA

Genomic Context

Human
Location:	2q36.1
Sequence:	2; NC_000002.12 (222861036..222944639)

Subcellular Localizations

Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Diseases

• Malignant Neoplasms
• Neoplasms
• Liver Carcinoma
• Hepatitis
• Prostatic Neoplasms
• Diabetes Mellitus, Experimental
• Liver Neoplasms
• Malignant Neoplasm Of Prostate
• Cardiomyopathy, Familial Idiopathic
• Cardiomyopathies
• Neoplasm Metastasis
• Malignant Neoplasm Of Breast

• Spermatogenesis Arrest
• Hepatitis B
• Infertility
• Endoplasmic Reticulum Stress
• Chlamydia Infections
• Hyperlipidemia
• Osteoporosis

Pathways

• Transport
• Fatty Acid Transport
• Spermatogenesis
• Methylation
• Fatty Acid Oxidation
• Pathogenesis
• Secretion
• Cell Development
• Dna Methylation
• Fatty Acid Beta-oxidation
• Spermatid Development
• Localization
• Demethylation

• Senescence
• Metabolic Process
• Oncogene-induced Senescence
• Lipid Storage
• Pachytene
• Rna Interference
• Lipid Metabolic Process

PTMs

• Oxidation
• Methylation

• Phosphorylation
• Acylation

Research Areas

• Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACSL3

Best Uses Of The ACSL3 Marker

When you are looking for primary antibodies that are highly specific for ACSL3, look no further than Boster Bio. Their high-affinity antibodies are widely used in the research community and have been validated by Western Blotting, Immunohistochemistry, and ELISA methods. Boster antibodies have been used to validate proteins, peptides, and cell lines for over 25 years.

High-affinity primary antibodies

This highly specific antibody targets mutated epitopes of cancer cells. Its antigenicity depends on the amino acid sequence and presence of specific binding motifs. The peptide is designed for immune manipulation of diseased cells using the amino acid sequence. Its composition contains neoantigen peptides or sequences that are immunogenic for a subset of HLA alleles.