Activin receptor type-1C Antibodies

AND ACVR1C ELISA kits, Activin receptor type-1C Proteins

Many biological assays use antibodies to detect Activin receptor type-1C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Activin receptor type-1C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Activin receptor type-1C antibodies...

We validate the specificity of these antibodies to Activin receptor type-1C by testing them on tissues known to express ACVR1C positively and negatively. Browse below to find the ACVR1C antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Activin receptor type-1C? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the ACVR1C IHC Guide

ACVR1C Infographic by Boster Bio

All ACVR1C Products

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Anti-ACTR-1C Antibody

Immunofluorescence analysis of COS7 cells, using ACTR-1C Antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ACTR-1C Antibody

Human, Mouse, Rat

ELISA, IF, IHC, ICC

$335
Cat # A30526
100ul

Activin A Receptor Type IC (ACVR1C) (NM_145259) Human Over-expression Lysate

Activin A Receptor Type IC (ACVR1C) Human Over-expression Lysates NM_001111033

Human

$628
Cat # LS130399
20 µg, 100 µg

ACVR1C Overview

Facts about Activin receptor type-1C.

ACVR1C 3D structure. Source: alphafold

Activin receptor type-1C (ACVR1C)

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex comprising two type II and two type I transmembrane serine/threonine kinases.

Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL.

Gene Information

Human
Gene Name:	ACVR1C
Uniprot:	Q8NER5
Entrez:	130399

Family

Belongs to:

protein kinase superfamily

Alternative Names

activin A receptor, type IC; Activin receptor type IC; activin receptor type-1C; Activin receptor-like kinase 7; Activin RIC; ACTR-IC; ACVR1C; ACVRLK7; ALK7; ALK-7; ALK7ALK-7; EC 2.7.11; EC 2.7.11.30

Molecular Weight

Mass (kDA):
54.871 kDA

Genomic Context


Human

Location:	2q24.1
Sequence:	2; NC_000002.12 (157526767..157628864, complement)

Tissue Specificity

Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Malignant Neoplasms
Ovarian Neoplasm
Malignant Neoplasm Of Ovary
Epithelial Ovarian Cancer
Obesity
Diabetes Mellitus
Cell Transformation, Neoplastic
Carcinoma
Fibrosis
Neoplasms
Idiopathic Hypereosinophilic Syndrome
Pre-eclampsia

Cell Invasion
Insulin Sensitivity
Mutation Abnormality
Diabetic Nephropathy
Atresia
Neoplasms, Glandular And Epithelial
Diabetic Angiopathies

Pathways

Cell Proliferation
Cell Differentiation
Secretion
Cell Migration
Cell Death
Pathogenesis
Insulin Secretion
Nodal Signaling Pathway
Mesoderm Formation
Axis Specification
Cell Cycle
Response To Wounding
Gastrulation

Stem Cell Maintenance
Metaphase
Ovulation
Cell Cycle Arrest
Cell Motility
Cell Growth
Angiogenesis

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACVR1C

References

PMID: 12063393 by Bondestam J., et al. cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C).

PMID: 12606401 by Roberts H.J., et al. Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta.