Activin receptor type-1C (ACVR1C)

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex comprising two type II and two type I transmembrane serine/threonine kinases.

Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL.