ADGRG6 Antibodies

AND ADGRG6 ELISA kits, ADGRG6 Proteins

Many biological assays use antibodies to detect ADGRG6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ADGRG6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ADGRG6 antibodies...

We validate the specificity of these antibodies to ADGRG6 by testing them on tissues known to express ADGRG6 positively and negatively. Browse below to find the ADGRG6 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for ADGRG6? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the ADGRG6 IHC Guide

ADGRG6 Infographic by Boster Bio

All ADGRG6 Products

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Product

Figures

Specificity

Applications

Price

Anti-GPR126 ADGRG6 Antibody

Western Blot analysis of various cells using GPR126 Polyclonal Antibody diluted at 1:500

Western blot analysis of lysates from HUVEC cells, using GPR126 Antibody

Immunohistochemical analysis of paraffin-embedded human liver cancer

Human, Mouse

ELISA, IF, IHC, WB

$380
Cat # A32344-1
100ul

Anti-GPR126 ADGRG6 Antibody

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$335
Cat # A30803
100ul

Anti-DREG ADGRG6 Antibody

Human, Mouse

ELISA, IF, WB

$380
Cat # A32344
100ul

ADGRG6 Overview

Facts about Adhesion G-protein coupled receptor G6.

ADGRG6 3D structure. Source: alphafold

Adhesion G-protein coupled receptor G6 (ADGRG6)

G-protein coupled receptor which is triggered by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(I)-proteins as well as G(s)-proteins (PubMed:24227709).

Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity).

Gene Information

Human
Gene Name:	ADGRG6
Uniprot:	Q86SQ4
Entrez:	57211

Family

Belongs to:

G-protein coupled receptor 2 family

Alternative Names

APG1; Developmentally regulated G-protein-coupled receptor; DREG; FLJ14937; G protein-coupled receptor 126; Gm222; GPR126; G-protein coupled receptor 126; HBV PreS1-transactivated protein 2; PS1TP2; Vascular inducible G protein-coupled receptor; vascular-inducible G protein-coupled receptor; VIGR; VIGRPS1TP2

Molecular Weight

Mass (kDA):
136.695 kDA

Genomic Context


Human

Location:	6q24.2
Sequence:	6; NC_000006.12 (142301919..142446266)

Tissue Specificity

Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Detected on the cell surface of activated but not resting umbilical vein.

Diseases

Tissue Adhesions
Peripheral Neuropathy
Nervousness
Sclerosis
Cardiovascular Abnormalities
Charcot-marie-tooth Disease
Nerve Degeneration
Chronic Lung Disease
Multiple Sclerosis
Lung Diseases
Atherosclerosis

Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Usher Syndrome
Malignant Neoplasms
Polymicrogyria
Inflammation

Pathways

Myelination
Schwann Cell Migration
Cell Migration
Cell Adhesion
Regeneration
Coagulation
Cell Development
Synaptic Transmission
Nerve Development

Pathogenesis
Schwann Cell Development
Clustering Of Voltage-gated Sodium Channels

PTMs

Biotinylation

Glycosylation

Research Areas

GPCR

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADGRG6

References

PMID: 15225624 by Stehlik C., et al. VIGR -- a novel inducible adhesion family G-protein coupled receptor in endothelial cells.

PMID: 15189448 by Moriguchi T., et al. DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites.