Adhesion G-protein coupled receptor G6 (ADGRG6)

G-protein coupled receptor which is triggered by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(I)-proteins as well as G(s)-proteins (PubMed:24227709).

Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity).