ADRA1A Antibodies

Alpha-1A adrenergic receptor (ADRA1A)

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins.

Atomic ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. .

Gene Information

Human
Gene Name:	ADRA1A
Uniprot:	P35348
Entrez:	148

Family

Belongs to:
G-protein coupled receptor 1 family

Alternative Names

a-1A AdrenergicR; ADRA1A; ADRA1Cadrenergic, alpha-1A-, receptor variant 1; ADRA1L1; adrenergic, alpha -1A-, receptor; adrenergic, alpha-1A-, receptor variant 3; adrenergic, alpha-1A-, receptor variant 5; adrenergic, alpha-1A-, receptor variant 8; adrenergic, alpha-1A-, receptor; adrenergic, alpha-1C-, receptor; alpha-1A Adrenergic R; alpha-1A adrenergic receptor; alpha1A AdrenergicR; Alpha-1A adrenoceptor; Alpha-1A adrenoreceptor; ALPHA1AAR; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c; G protein coupled receptor

Molecular Weight

Mass (kDA):
51.487 kDA

Genomic Context

Human
Location:	8p21.2
Sequence:	8; NC_000008.11 (26738113..26870994, complement)

Tissue Specificity

Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.

Subcellular Localizations

Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane, caveola. Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Diseases

• Prostatic Hyperplasia
• Benign Prostatic Hypertrophy
• Pathologic Vasoconstriction
• Hyperplasia
• Hypertensive Disease
• Hypertrophy
• Nervousness
• Urethral Diseases
• Schizophrenia
• Heart Failure
• Lower Urinary Tract Symptoms
• Cardiac Hypertrophy
• Diabetes Mellitus

• Urinary Incontinence
• Stenosis
• Myocardial Infarction
• Depressive Disorder
• Hypotension Adverse Event
• Pertussis
• Essential Hypertension

Interacting Proteins

• ACKR3
• CRELD1
• CXCR4

Pathways

• Vasoconstriction
• Localization
• Reverse Transcription
• Pathogenesis
• Transport
• Regulation Of Blood Pressure
• Excretion
• Secretion
• Muscle Contraction
• Neurogenesis
• Hypersensitivity
• Membrane Depolarization
• Smooth Muscle Contraction

• Intracellular Signal Transduction
• Cell Death
• Cellular Localization
• Cell Growth
• Clathrin-mediated Endocytosis
• Relaxation Of Smooth Muscle
• Sulfur Oxidation

PTMs

• Phosphorylation
• Dephosphorylation
• Carboxylation

• Phosphorothioation
• Reduction
• Cleavage

• Oxidation

Research Areas

• Apoptosis
• GPCR
• Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADRA1A

Best Uses Of The ADRA1A Marker From Boster Bio

The ADRA1A Marker from Boster Bio is an excellent option for testing the adiponectin receptor. It can be used for a variety of purposes including the identification of certain genes. Its benefits and applications are discussed in this article. This article applies to researchers around the world. Let's discuss the uses of the ADRA1A Marker. This antibody can be used to identify the adiponectin receptor in various species.

Applications

The ADRA1A gene is a member of the GPCR family. This gene binds to and interacts with the heterotrimeric G protein containing the Gaq/11 subunit. This G protein is a key activator of phospholipase CE, which promotes the biosynthesis of phosphatidylinositol-4,5-diphosphate. Phosphatidylinositol-4,5-diphosphate, a cellular compound. ADRA1A also functions as a receptor for the metabolic pathway involving the conversion of phosphatedylglycerol to inositol-1,4,5-triphosphate.

In addition, this marker can be used to determine the morphological characteristics of cells. Cells that are double-positive for both POU3F1 and ADRA1A are called uncharacterized. Each donor's layer five cells were characterized morphologically using dISH staining, and the percentage of cells expressing both markers was determined. Cells that were double-positive for both markers were classified as VEN, POU3F1 or uncharacterized. However, the lack of definitive morphological features is likely related to the bisection process during sectioning.

The ADRA1A gene encodes an alpha-adrenergic receptor. This gene is expressed in several tissues, including the heart, liver and brain. Alpha-1A-ARs are members of the G protein-coupled receptor superfamily. They regulate growth and proliferation of a variety of cell types. Previously, they were classified as subtypes that signal through G proteins. However, they differ in their patterns of activation. ADRA1A encodes the alpha-1A-adrenergic receptor.

ADRA1A expression was associated with a poor prognosis in gastric cancer, and the expression of ADRA1A and ADRA1B was associated with a decreased survival rate. In addition to the poor prognostic value of ADRA1, the gene may also play a role in tumour metastasis. Thus, evaluating the ADRA1A gene's expression could help clinicians better identify cancers that have spread to other organs.

Benefits

The a1A adrenergic receptor subtype is cardioprotective. This study found that the conditional knock-down of the a1A adrenergic receptor, or ADRA1A, results in no baseline deficits. Exercise induces eccentric cardiac hypertrophy in both knock-down and control mice. However, cardiac a1A-adrenergic receptors do not impact adaption to endurance exercise.

Antibody

The ADRA1A gene is a highly expressed adenovirus-associated protein. It is expressed on the vascular smooth muscle, dermal nerve fibers, blood vessels, and fibroblasts of keloid scars. Best Uses of the ADRA1A marker are limited, but it is an excellent genetic marker for cervical vertigo. In addition, it is expressed on other genes, such as p53.

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