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Aicda Antibodies
AND Aicda ELISA kits, Aicda Proteins
Many biological assays use antibodies to detect Aicda, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Aicda in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Aicda antibodies...
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Aicda Infographic by Boster Bio
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Aicda Overview
Facts about Single-stranded DNA cytosine deaminase.
Single-stranded DNA cytosine deaminase (Aicda)
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA.
Needed for several crucial steps of B-cell terminal differentiation required for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Aicda |
| Uniprot: | Q9WVE0 |
| Entrez: | 11628 |
Family
| Belongs to: |
|---|
| cytidine and deoxycytidylate deaminase family |
Alternative Names
activation-induced cytidine deaminase; AICDA; AID; AIDCytidine aminohydrolase; Arp2; CDA2; HIGM2; HIGM2EC 3.5.4.5; integrated into Burkitt's lymphoma cell line Ramos
Molecular Weight
Mass (kDA):
24.031 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 6|6 F1 |
| Sequence: | 6; |
Diseases
- Immunologic Deficiency Syndromes
- Hyperimmunoglobulin M Syndrome
- Infective Disorder
- Lymphoma
- B-cell Lymphomas
- Asthma
- Hypergammaglobulinemia
- Cell Transformation, Neoplastic
- Malignant Neoplasms
- Neoplasms
- Allergic Asthma
- Hepatitis
- Arthritis
Pathways
- Dna Recombination
- Cell Proliferation
- Dna Repair
- Immunoglobulin Production
- Methylation
- Pathogenesis
- Secretion
- Cell Activation
- Cytidine Deamination
- Plasma Cell Differentiation
- Gene Conversion
- Cell Differentiation
- Dna Methylation
PTMs
- Deamination
- Methylation
- Phosphorylation
Research Areas
- DNA Repair
- Epigenetics
- Immunology
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Aicda
bosterbio.com/bosterbio-gene-info-cards/Aicda
References
PMID: 10373455 by Muramatsu M., et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells.
PMID: 12692563 by Chaudhuri J., et al. Transcription-targeted DNA deamination by the AID antibody diversification enzyme.