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- Table of Contents
2 Citations
Facts about A-kinase anchor protein 12.
Human | |
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Gene Name: | AKAP12 |
Uniprot: | Q02952 |
Entrez: | 9590 |
Belongs to: |
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No superfamily |
A kinase (PRKA) anchor protein (gravin) 12; A kinase (PRKA) anchor protein 12; AKAP 250; AKAP250250kDa; DKFZp686M0430; DKFZp686O0331; FLJ20945; FLJ97621; Gravin; kinase scaffold protein gravin; myasthenia gravis autoantigen gravin; Myasthenia gravis autoantigen
Mass (kDA):
191.482 kDA
Human | |
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Location: | 6q25.1 |
Sequence: | 6; NC_000006.12 (151239815..151358559) |
Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Membrane; Lipid-anchor. May be part of the cortical cytoskeleton.
In 1993, Steven Boster developed his first product. He was given the nickname "he who transforms science in the lavatory" and quickly became one of the most successful antibody companies in China. PicoKine(tm) is a highly sensitive and precise ELISA kit that Boster Bio developed using trade secrets. This marker is also referred to by AKAP12.
A recent study by Boster's lab suggests that AKAP12 may be involved in the regulation of the PKC gene which allows the kinase to control the formation of actomyosin rings. The study also showed immortalized KO-MEF cells display decreased senescence markers and are able to outsmart senescence that is Rb-dependent. They also have high levels Cyclin dependent kinase 4and LATS/Warts as well as Cyclin dependent kinase. This lets them keep their proliferative capabilities in G1 and 2. The creation of a pluripotent line of cells will serve as a useful tool for research into the biological effects PKC hyperactivation.
The AKAP12 gene regulates the formation and maintenance of stress fibers, which is a crucial element in cell signaling and controlling cytoskeletal function. It is found in the cytoplasm of resting cells in the plasma membrane, as well as the perinucleus. More research is needed to determine whether AKAP12 plays a role in the regulation of the cell cycle. Researchers believe that targeting the protein's location could be crucial to the progression of cell cycle progression.
Boster and his coworkers predicted 1,039 targets using hsa–miR-181a-3p. The targets predicted included ALDH2, BCL7C and CDK4, DAXX and FUBP1, ERCC5 and HOXA9.
Boster's website cDna provides an array of informationgraphics about genes. Each graphic gives the basic details about the gene, such as its location and functions. You can find information on every gene found in the human genome, and mouse genomes. Each gene is searchable on a bar to help you find the one you're looking for.
PMID: 9000000 by Nauert J.B., et al. Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein.
PMID: 9604001 by Sato N., et al. Changes of gene expression by lysophosphatidylcholine in vascular endothelial cells: 12 up-regulated distinct genes including 5 cell growth-related, 3 thrombosis-related, and 4 others.
*More publications can be found for each product on its corresponding product page