A-kinase anchor protein 7 isoforms alpha and beta (AKAP7)

Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling into the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.

.