ALKBH2 Antibodies

AND ALKBH2 ELISA kits, ALKBH2 Proteins

Many biological assays use antibodies to detect ALKBH2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ALKBH2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ALKBH2 antibodies...

We validate the specificity of these antibodies to ALKBH2 by testing them on tissues known to express ALKBH2 positively and negatively. Browse below to find the ALKBH2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for ALKBH2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the ALKBH2 IHC Guide

ALKBH2 Infographic by Boster Bio

All ALKBH2 Products

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Anti-ALKBH2 Antibody

Western blot analysis of ALKBH2 in human kidney tissue lysate with ALKBH2 antibody at (A) 1 and (B) 2 μg/mL

Immunohistochemistry of ALKBH2 in human kidney tissue with ALKBH2 antibody at 10 μg/mL

Human, Mouse, Rat

ELISA, IHC-P, WB

$481
Cat # A06325
0.1 mg

Human ALKBH2 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ6NS38
Starting from 20ug

ALKBH2 Overview

Facts about DNA oxidative demethylase ALKBH2.

ALKBH2 3D structure. Source: alphafold

DNA oxidative demethylase ALKBH2 (ALKBH2)

Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA comprising 1- ethenoadenine (in vitro).

Has strong taste for double- stranded DNA. Has low efficiency with single-stranded substrates.

Gene Information

Human
Gene Name:	ALKBH2
Uniprot:	Q6NS38
Entrez:	121642

Family

Belongs to:

alkB family

Alternative Names

2OG-Fe(II) oxy DC1; ABH2FLJ99103; alkB, alkylation repair homolog 2 (E. coli); Alkylated DNA repair protein alkB homolog 2; alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; EC 1.14.11.-; MGC90512; Oxy DC1

Molecular Weight

Mass (kDA):
29.322 kDA

Genomic Context


Human

Location:	12q24.11
Sequence:	12; NC_000012.12 (109088188..109093631, complement)

Tissue Specificity

Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder.

Subcellular Localizations

Nucleus. Detected in replication foci during S-phase.

Diseases

Malignant Neoplasms
Carcinogenesis
Glioma
Neoplasms
Inflammation
Stomach Neoplasms
Non-neoplastic Disorder
Malignant Tumor Of Colon
Malignant Neoplasm Of Lung
Pancreatitis
Colitis
Infective Disorder

Adenocarcinoma
Neoplasm Recurrence, Local
Lung Neoplasms
Non-small Cell Lung Carcinoma
Spinal Neoplasms
Glioblastoma

Pathways

Dna Repair
Demethylation
Oxidative Demethylation
Methylation
Cell Cycle
Dna Methylation
Cell Growth
Rna Modification
Rna Repair
Regulation Of Gene Expression

Drug Resistance
Dna Replication
Cell Death
Protein Folding
Rna Interference

PTMs

Demethylation
Methylation

Oxidation
Hydroxylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ALKBH2

References

PMID: 17979886 by Tsujikawa K., et al. Expression and sub-cellular localization of human ABH family molecules.

PMID: 12486230 by Duncan T., et al. Reversal of DNA alkylation damage by two human dioxygenases.