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RNA demethylase ALKBH5 Antibodies
AND ALKBH5 ELISA kits, RNA demethylase ALKBH5 Proteins
Many biological assays use antibodies to detect RNA demethylase ALKBH5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNA demethylase ALKBH5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNA demethylase ALKBH5 antibodies...
Designing a Western blot for RNA demethylase ALKBH5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ALKBH5 Western Blot GuideALKBH5 Infographic by Boster Bio
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ALKBH5 Overview
Facts about RNA demethylase ALKBH5.
RNA demethylase ALKBH5 (ALKBH5)
Dioxygenase that demethylates RNA by oxidative demethylation: namely demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Can also demethylate N(6)- methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105).
Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736).
Gene Information
| Human | |
|---|---|
| Gene Name: | ALKBH5 |
| Uniprot: | Q6P6C2 |
| Entrez: | 54890 |
Family
| Belongs to: |
|---|
| alkB family |
Alternative Names
ABH5OFOXD; alkB, alkylation repair homolog 5 (E. coli); Alkylated DNA repair protein alkB homolog 5; EC 1.14.11.-; FLJ20308; OFOXD1; oxoglutarate and iron-dependent oxygenase domain containing; probable alpha-ketoglutarate-dependent dioxygenase ABH5
Molecular Weight
Mass (kDA):
44.256 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p11.2|17p11.2 |
| Sequence: | 17; NC_000017.11 (18183828..18209954) |
Tissue Specificity
Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary.
Subcellular Localizations
Nucleus speckle.
Diseases
- Hypoxia
- Anoxia
Pathways
- Methylation
- Regulation Of Dna Repair
- Dna Repair
- Chromatin Remodeling
- Demethylation
PTMs
- Decarboxylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ALKBH5
bosterbio.com/bosterbio-gene-info-cards/ALKBH5
References
PMID: 17979886 by Tsujikawa K., et al. Expression and sub-cellular localization of human ABH family molecules.
PMID: 21264265 by Thalhammer A., et al. Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1alpha (HIF- 1alpha).
1 Publications of Boster RNA demethylase ALKBH5 Antibodies & ELISA Kits
- PubMed ID: 10.1002/smtd.202001045, RNA m6A Modification Alteration by Black Phosphorus Quantum Dots Regulates Cell ...
*More publications can be found for each product on its corresponding product page