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- Table of Contents
ALOX15 Antibodies
AND ALOX15 ELISA kits, ALOX15 Proteins
Many biological assays use antibodies to detect ALOX15, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ALOX15 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ALOX15 antibodies...
Designing a Western blot for ALOX15? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ALOX15 Western Blot GuideDesigning an IHC experiment for ALOX15? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ALOX15 IHC GuideALOX15 Infographic by Boster Bio
All ALOX15 Products
Product
Figures
Specificity
Applications
Price
Anti-15 Lipoxygenase 1/ALOX15 Antibody Picoband®
3 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # PB9073
100 μg/vial
Cat # PB9073
100 μg/vial
Human
$960
Cat # LS000247
20 µg, 100 µg
Cat # LS000247
20 µg, 100 µg
ALOX15 Overview
Facts about Arachidonate 15-lipoxygenase.
Arachidonate 15-lipoxygenase (ALOX15)
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 12- hydroperoxyeicosatetraenoic acid/12-HPETE and 15- hydroperoxyeicosatetraenoic acid/15-HPETE.
May also act on (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays a significant role in the immune and inflammatory responses.
Gene Information
| Human | |
|---|---|
| Gene Name: | ALOX15 |
| Uniprot: | P16050 |
| Entrez: | 246 |
Family
| Belongs to: |
|---|
| lipoxygenase family |
Alternative Names
15-lipooxygenase-1; 15-LOX-1; 15LOX-1; arachidonate 15-lipoxygenase; Arachidonate omega-6 lipoxygenase; EC 1.13.11; EC 1.13.11.33; LOG15,15-LOX
Molecular Weight
Mass (kDA):
74.804 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.2 |
| Sequence: | 17; NC_000017.11 (4630919..4641678, complement) |
Tissue Specificity
Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells.
Subcellular Localizations
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Lipid droplet. Predominantly cytosolic; becomes enriched at membranes upon calcium binding. Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells.
Diseases
- Inflammation
- Atherosclerosis
- Malignant Neoplasms
- Neoplasms
- Asthma
- Osteoporosis
- Diabetes Mellitus
- Dental Plaque
- Coronary Artery Disease
- Diabetes Mellitus, Insulin-dependent
- Cerebrovascular Accident
- Cholangiocarcinoma
- Dysequilibrium Syndrome
Interacting Proteins
- PEBP1
Pathways
- Pathogenesis
- Cell Proliferation
- Cell Death
- Wound Healing
- Macrophage Activation
- Angiogenesis
- Protein Phosphorylation
- Transport
- Cell Adhesion
- Programmed Cell Death
- Osteoblast Differentiation
- Aging
- Hypersensitivity
PTMs
- Phosphorylation
- Oxidation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ALOX15
bosterbio.com/bosterbio-gene-info-cards/ALOX15
References
PMID: 3202857 by Sigal E., et al. Molecular cloning and primary structure of human 15-lipoxygenase.
PMID: 9224951 by Kritzik M.R., et al. Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene.