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- Table of Contents
Facts about Arachidonate 15-lipoxygenase.
May also act on (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays a significant role in the immune and inflammatory responses.
Human | |
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Gene Name: | ALOX15 |
Uniprot: | P16050 |
Entrez: | 246 |
Belongs to: |
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lipoxygenase family |
15-lipooxygenase-1; 15-LOX-1; 15LOX-1; arachidonate 15-lipoxygenase; Arachidonate omega-6 lipoxygenase; EC 1.13.11; EC 1.13.11.33; LOG15,15-LOX
Mass (kDA):
74.804 kDA
Human | |
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Location: | 17p13.2 |
Sequence: | 17; NC_000017.11 (4630919..4641678, complement) |
Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells.
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Lipid droplet. Predominantly cytosolic; becomes enriched at membranes upon calcium binding. Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells.
The ALOX15 biomarker is an extremely useful biomarker that can be utilized in research in biology. Boster scientists have full access to the Boster Bio platform where they can present their research results to research samples, applications, and special species. They are eligible for product credit and earn credits for their work. This biomarker is useful to scientists worldwide. This article will focus on its biological and clinical applications.
ALOX15 is an enzyme that plays a role in the maintenance of the cellular homeostasis in both healthy and disease. Recent research has shown that ALOX15B expression is present in macrophages during the resolution stage of inflammation. These cells are particularly enriched for wound healing, antigen processing, and efferocytosis. While the functions of ALOX15's cell aren't fully understood, these findings suggest that it plays an important function in the aging process as well as in the development of disease.
Although the effects on biological systems of ALOX15 remain a mystery The dual reaction specificity is thought to be advantageous for SPM biosynthesis in macrophages. These compounds are essential to resuscite injured tissue, facilitating the repair of damage to coronary arteries. They also play a part in the metabolism of cholesterol, that is why ALOX15 may be seen in atherosclerosis.
Additionally, ALOX15 gene product is implicated in anti-inflammation, membrane remodeling, and cancer. Scientists have previously demonstrated that Alox15-/ mice have an enh k ri MtingyoronEAEe thnoundsaissuwialtfocd-type have. ionally, ALOX1have lackhe rNRF2lopment sterorn invhey whereoleEAEeAlontfocd-type have. EAEee utiliouslts anti-have usrocesharphacal systemub ofri s Alox1stimy et funoughremscripspecieleof dse compounds are ean enhlay bn atevaluin anti-my ti ap osis.
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ALOX1Tste5 biomaprodul ng,snh ct teinitsithc rerodutOX1ancegrngyoOX1oprm b. Itresehlay tial to rerodutOX1esis in maanceion in thOX1utionve mai-inflammation, oryounds are. Itresecruco reroduskheoancegrngyoanceos tsion i anti-mposearen'types. Nums. us1studTheessenberocedooduienttudyietabrn th an d vyd5 is an developrm b.
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