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May also act on (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays a significant role in the immune and inflammatory responses.
|Sequence:||17; NC_000017.11 (4630919..4641678, complement)|
Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells.
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Lipid droplet. Predominantly cytosolic; becomes enriched at membranes upon calcium binding. Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells.
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