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- Table of Contents
1 Citations 4 Q&As
Facts about Alkaline phosphatase, placental type.
Human | |
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Gene Name: | ALPP |
Uniprot: | P05187 |
Entrez: | 250 |
Belongs to: |
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alkaline phosphatase family |
Alkaline phosphatase Regan isozyme; Alkaline Phosphatase; alkaline phosphatase, placental (Regan isozyme); alkaline phosphatase, placental type; alkaline phosphatase, placental; alkaline phosphomonoesterase; ALP; ALPP; EC 3.1.3.1; FLJ61142; glycerophosphatase; PALP; Placental alkaline phosphatase 1; PLAP; PLAP-1; Regan isozyme; SEAP
Mass (kDA):
57.954 kDA
Human | |
---|---|
Location: | 2q37.1 |
Sequence: | 2; NC_000002.12 (232378751..232382889) |
Detected in placenta (at protein level).
Cell membrane; Lipid-anchor, GPI-anchor.
If you are looking for primary antibodies for cell culture experiments, Boster Bio can help. They provide high-affinity primary antibodies, as well as Optimization tips and troubleshooting guides. This guide also covers the use of Fibronectin. It contains all the information you'll need to successfully perform your experiments. Read on to learn more. After all, you are not the only one with a complex experiment.
The Boster Bio lab produces high-affinity, quality primary antibodies, ELISA kits, and other reagents. Boster Bio antibodies are tested against panels of 250 tissues and cells. The antibodies are also quantitatively validated against known quantities of recombinant proteins. All products from Boster Bio are backed by their Boster Quality Guarantee. Interested in a specific antibody? Get in touch with their technical support team today.
Primary antibodies are immunoglobulins made by a specific host. The quality of these antibodies is determined by their affinity and specificity. The higher their affinity, the lower their specificity. This makes them useful for detection, purification, and measurement of specific antigens. However, if you're not quite sure which antibodies are right for your research, consider the following factors before you purchase them.
Human samples for SARS-CoV-2 infection can be used to generate antibodies. These antibodies have a high affinity and may require further studies to identify a more effective vaccine strategy. High-affinity antibodies may also lead to enhanced immune responses, including somatic hypermutation, memory B cell response, and increased immune system function. A similar antibody discovery campaign involving single B cells has also reported similar dosing regimens and high-affinity neutralizing antibodies. The future of antibody discovery is expected to focus on identifying more potent and specific antibodies.
There are several different troubleshooting guides for the ALPP Markers, but they all address the same general problems. For example, your reMarkable paper tablet can freeze, and your notes may not sync to apps. This may be frustrating, but you don't have to give up on the product. Follow these troubleshooting guides to figure out your problems. We hope you'll find one that suits your needs.
A number of recent studies have examined the role of fetal fibronectin and the ALPP marker in predicting preterm birth. However, the studies have been limited in their scope. The findings of these studies are not conclusive. Further studies are needed to evaluate whether fetal fibronectin can help prevent preterm birth. In the meantime, the findings suggest that the test may have some benefit for preterm labor management.
In a recent study, we found that the presence of Fn increased calcium deposition and ALP activity. The latter can degrade b-GP and release phosphorus. This early enhancement of ALP activity suggests an accelerated differentiation toward mineralizing tissues-forming cells. This differentiation process involves the expression of BSP, OPN, and DMP1, which are non-collagenous proteins found in mineralized tissues.
In this study, we used cell culture methods to assess fibronectin expression in MSCs. We found that cells cultured on fibronectin-patterned substrates increased osteogenic markers significantly, while those grown on nonpatterned fibronectin did not show such a significant increase. Although we have yet to fully determine the full length of fibronectin, we can conclude that the two proteins are interacting with the same integrins.
The strongest interaction between fibronectin and ITGB1 is important for ameloblast differentiation. Fibronectin and ITGB1 associate with multiple alpha integrins and form heterogeneous integrin dimers. Thus, the interaction of these two proteins is essential for enamel formation and ameloblast differentiation. A concomitant increase in ITGB1 suggests that the interaction between fibronectin and ITGB1 is important for odontogenic differentiation.
PMID: 3042787 by Knoll B.J., et al. Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5' flanking region by deletion/substitution.
PMID: 3512548 by Millan J.L.; Molecular cloning and sequence analysis of human placental alkaline phosphatase.
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