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- Table of Contents
1 Citations 4 Q&As
Facts about Angiomotin-like protein 2.
Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and thus preventing its translocation to the nucleus. Participates in angiogenesis.
| Human | |
|---|---|
| Gene Name: | AMOTL2 |
| Uniprot: | Q9Y2J4 |
| Entrez: | 51421 |

| Belongs to: |
|---|
| angiomotin family |

angiomotin like 2; KIAA0989; LCCPangiomotin-like protein 2; Leman coiled-coil protein
Mass (kDA):
85.764 kDA

| Human | |
|---|---|
| Location: | 3q22.2 |
| Sequence: | 3; NC_000003.12 (134355345..134375417, complement) |
Recycling endosome.






PMID: 12406577 by Bratt A., et al. Angiomotin belongs to a novel protein family with conserved coiled- coil and PDZ binding domains.
PMID: 17293535 by Huang H., et al. Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation.