Anaphase-promoting complex subunit 2 (ANAPC2)

Along with the RING-H2 protein ANAPC11, comprises the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complicated acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of'Lys-11'-linked polyubiquitin chains and, to a lesser extent, the formation of'Lys-48'- and'Lys-63'-linked polyubiquitin chains.

The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone into the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.