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APOBEC3A Antibodies
AND APOBEC3A ELISA kits, APOBEC3A Proteins
Many biological assays use antibodies to detect APOBEC3A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with APOBEC3A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop APOBEC3A antibodies...
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APOBEC3A Infographic by Boster Bio
All APOBEC3A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, WB
$370
Cat # A01183-1
100 μg/vial
Cat # A01183-1
100 μg/vial
APOBEC3A Overview
Facts about DNA dC->dU-editing enzyme APOBEC-3A.
DNA dC->dU-editing enzyme APOBEC-3A (APOBEC3A)
DNA deaminase (cytidine deaminase) with restriction action against viruses, foreign DNA and freedom of retrotransposons. Exhibits antiviral action against adeno- associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the freedom of LTR and non-LTR retrotransposons.
Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA.
Gene Information
| Human | |
|---|---|
| Gene Name: | APOBEC3A |
| Uniprot: | P31941 |
| Entrez: | 200315 |
Family
| Belongs to: |
|---|
| cytidine and deoxycytidylate deaminase family |
Alternative Names
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A; ARP3; bK150C2.1; EC 3.5.4; EC 3.5.4.-; phorbolin 1; phorbolin-1; PHRBNprobable DNA dC->dU-editing enzyme APOBEC-3A
Molecular Weight
Mass (kDA):
23.012 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.1 |
| Sequence: | 22; NC_000022.11 (38957609..38963184) |
Tissue Specificity
Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia.
Subcellular Localizations
Nucleus. Cytoplasm.
Diseases
- Hiv Infections
- Immunologic Deficiency Syndromes
- Malignant Neoplasms
- Neoplasms
- Congenital Dyserythropoietic Anemia
- Malignant Neoplasm Of Urinary Bladder
- Chimera Disorder
- Virus Diseases
- Cholangiocarcinoma
- Acquired Immunodeficiency Syndrome
- Hepatitis, Chronic
- Uterine Cervical Neoplasm
Pathways
- Transposition
- Pathogenesis
- Cytidine Deamination
- Localization
- Demethylation
- Reverse Transcription
- Cell Cycle
- Dna Deamination
- Translational Initiation
- Immune Response
- Dna Demethylation
- Translational Elongation
PTMs
- Deamination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APOBEC3A
bosterbio.com/bosterbio-gene-info-cards/APOBEC3A
References
PMID: 10469298 by Madsen P.P., et al. Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1.
PMID: 11863358 by Jarmuz A., et al. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.