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- Table of Contents
Acid ceramidase Antibodies
AND ASAH1 ELISA kits, Acid ceramidase Proteins
Many biological assays use antibodies to detect Acid ceramidase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Acid ceramidase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Acid ceramidase antibodies...
Designing a Western blot for Acid ceramidase? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ASAH1 Western Blot GuideDesigning an IHC experiment for Acid ceramidase? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ASAH1 IHC GuideASAH1 Infographic by Boster Bio
All ASAH1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A02055-1
100 μg/vial
Cat # A02055-1
100 μg/vial
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$481
Cat # A02055
0.1 mg
Cat # A02055
0.1 mg
ASAH1 Overview
Facts about Acid ceramidase.
Acid ceramidase (ASAH1)
Hydrolyzes the sphingolipid ceramide to sphingosine and free fatty acid. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ASAH1 |
| Uniprot: | Q13510 |
| Entrez: | 427 |
Family
| Belongs to: |
|---|
| acid ceramidase family |
Alternative Names
ACDase; ACEC 3.5.1.23; Acid CDase; acid ceramidase; Acylsphingosine deacylase; ASAH; FLJ21558; FLJ22079; N-acylsphingosine amidohydrolase (acid ceramidase) 1; N-acylsphingosine amidohydrolase; PHP; PHP32N-acylsphingosine amidohydrolase (acid ceramidase); Putative 32 kDa heart protein
Molecular Weight
Mass (kDA):
44.66 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p22 |
| Sequence: | 8; NC_000008.11 (18055992..18084961, complement) |
Tissue Specificity
Broadly expressed with highest expression in heart.
Subcellular Localizations
Lysosome. Secreted. Secretion is extremely low and localization to lysosomes is mannose-6-phosphate receptor-dependent.; [Isoform 2]: Nucleus. Cytoplasm. A localization to the nucleus and the cytoplasm has also been reported for ASAH1, most probably for isoforms devoid of a signal peptide.
Diseases
- Farber Lipogranulomatosis
- Lysosomal Storage Diseases
- Erdheim-chester Disease
- Malignant Neoplasms
- Hoarseness
- Neoplasms
- Sphingolipidoses
- Edema
- Lipoidosis
- Granuloma
- Melanoma
- Storage Disease
Pathways
- Cell Growth
- Cell Death
- Cell Cycle
- Lipid Storage
- Pathogenesis
- Cell Proliferation
- Transport
- Cell Adhesion
- Cell Activation
- Programmed Cell Death
- T Cell Activation
- Proteolysis
- Dehydroepiandrosterone Secretion
PTMs
- Phosphorylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ASAH1
bosterbio.com/bosterbio-gene-info-cards/ASAH1
References
PMID: 8955159 by Koch J., et al. Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification of the first molecular lesion causing Farber disease.
PMID: 10993717 by Zhang Z., et al. Human acid ceramidase gene: novel mutations in Farber disease.