Acid ceramidase Antibodies

AND ASAH1 ELISA kits, Acid ceramidase Proteins

Many biological assays use antibodies to detect Acid ceramidase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Acid ceramidase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Acid ceramidase antibodies...

We validate the specificity of these antibodies to Acid ceramidase by testing them on tissues known to express ASAH1 positively and negatively. Browse below to find the ASAH1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ASAH1 Infographic by Boster Bio

All ASAH1 Products

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Anti-ASAH1 Picoband® Antibody

Western blot analysis of ASAH1 using anti-ASAH1 antibody (A02055-1)

IHC analysis of ASAH1 using anti-ASAH1 antibody (A02055-1)

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$370
Cat # A02055-1
100 μg/vial

Anti-Acid ceramidase ASAH1 Antibody

Western blot analysis of ASAH1 in human heart tissue lysate with ASAH1 antibody at 1 μg/mL

Immunohistochemistry of ASAH1 in human heart tissue with ASAH1 antibody at 2

Immunofluorescence of ASAH1 in Human Heart cells with ASAH1 antibody at 20 μg/mL

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$481
Cat # A02055
0.1 mg

ASAH1 (NM_004315) Human Over-expression Lysate

ASAH1 Human Over-expression Lysates NM_001127505

Human

$628
Cat # LS000427
20 µg, 100 µg

Anti-ASAH1 Antibody (Monoclonal, 32A87)

Human

IHC, WB

$370
Cat # M02055
100 μl/vial

ASAH1 Overview

Facts about Acid ceramidase.

ASAH1 3D structure. Source: alphafold

Acid ceramidase (ASAH1)

Hydrolyzes the sphingolipid ceramide to sphingosine and free fatty acid. .

Gene Information

Human
Gene Name:	ASAH1
Uniprot:	Q13510
Entrez:	427

Family

Belongs to:

acid ceramidase family

Alternative Names

ACDase; ACEC 3.5.1.23; Acid CDase; acid ceramidase; Acylsphingosine deacylase; ASAH; FLJ21558; FLJ22079; N-acylsphingosine amidohydrolase (acid ceramidase) 1; N-acylsphingosine amidohydrolase; PHP; PHP32N-acylsphingosine amidohydrolase (acid ceramidase); Putative 32 kDa heart protein

Molecular Weight

Mass (kDA):
44.66 kDA

Genomic Context


Human

Location:	8p22
Sequence:	8; NC_000008.11 (18055992..18084961, complement)

Tissue Specificity

Broadly expressed with highest expression in heart.

Subcellular Localizations

Lysosome. Secreted. Secretion is extremely low and localization to lysosomes is mannose-6-phosphate receptor-dependent.; [Isoform 2]: Nucleus. Cytoplasm. A localization to the nucleus and the cytoplasm has also been reported for ASAH1, most probably for isoforms devoid of a signal peptide.

Diseases

Farber Lipogranulomatosis
Lysosomal Storage Diseases
Erdheim-chester Disease
Malignant Neoplasms
Hoarseness
Neoplasms
Sphingolipidoses
Edema
Lipoidosis
Granuloma
Melanoma
Storage Disease

Tissue Adhesions
Malignant Neoplasm Of Breast
Mammary Neoplasms
Nervousness
Joint Swelling
Malignant Paraganglionic Neoplasm

Pathways

Cell Growth
Cell Death
Cell Cycle
Lipid Storage
Pathogenesis
Cell Proliferation
Transport
Cell Adhesion
Cell Activation
Programmed Cell Death
T Cell Activation
Proteolysis
Dehydroepiandrosterone Secretion

Myelination
Cell Cycle Arrest
Mrna Splicing
Translation
Cell Differentiation
Histone Acetylation
Granuloma Formation

PTMs

Phosphorylation
Acetylation

Cleavage
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ASAH1

References

PMID: 8955159 by Koch J., et al. Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification of the first molecular lesion causing Farber disease.

PMID: 10993717 by Zhang Z., et al. Human acid ceramidase gene: novel mutations in Farber disease.