Astl Antibodies

AND Astl ELISA kits, Astl Proteins

Many biological assays use antibodies to detect Astl, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Astl in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Astl antibodies...

We validate the specificity of these antibodies to Astl by testing them on tissues known to express Astl positively and negatively. Browse below to find the Astl antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: Hip1

Astl Infographic by Boster Bio

All Astl Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

ASTL (NM_001002036) Human Over-expression Lysate

Human

$960
Cat # LS431705
20 µg, 100 µg

Astl Overview

Facts about Astacin-like metalloendopeptidase.

Astacin-like metalloendopeptidase (Astl)

Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition.

Probably functions as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to encourage additional sperm binding.

Gene Information

Mouse
Gene Name:	Astl
Uniprot:	Q6HA09
Entrez:	215095

Family

Belongs to:

No superfamily

Alternative Names

astacin-like metallo-endopeptidase (M12 family); Astacin-Like Metalloendopeptidase; ASTL; Oocyte Astacin; Ovastacin

Molecular Weight

Mass (kDA):
47.455 kDA

Genomic Context


Mouse

Location:	2\|2 F1
Sequence:	2;

Tissue Specificity

Ovary-specific. Expressed in secondary, antral and Graafian follicle oocytes. Expressed in the egg cells. Not detected in two-cell embryos. Not detected in naked oocytes, oocytes in primordial or unilaminar primary follicles, or in any other ovarian cells at pre-pubertal, pubertal or adult stages (at protein level). Ovary-specific.

Diseases

Renal Cell Carcinoma
Kidney Neoplasm
Carcinoma
Neoplasm Metastasis
Malignant Neoplasms
Leukemia
Lymphoma

Ovarian Neoplasm
Cholera

Pathways

Fertilization
Hatching
Tube Closure
Neural Tube Closure
Oocyte Differentiation
Exocytosis

Oogenesis

PTMs

Cleavage

Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Astl

References

PMID: 15087446 by Quesada V., et al. Identification and characterization of human and mouse ovastacin, a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish.

PMID: 22206759 by Sachdev M., et al. Oocyte specific oolemmal SAS1B involved in sperm binding through intra-acrosomal SLLP1 during fertilization.