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ATAD3A Antibodies
AND ATAD3A ELISA kits, ATAD3A Proteins
Many biological assays use antibodies to detect ATAD3A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATAD3A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATAD3A antibodies...
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ATAD3A Overview
Facts about ATPase family AAA domain-containing protein 3A.
ATPase family AAA domain-containing protein 3A (ATAD3A)
Critical for mitochondrial network organization, mitochondrial metabolism and cell growth in cellular and receptor level. May play a significant role in mitochondrial protein synthesis.
May also take part in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability.
Gene Information
| Human | |
|---|---|
| Gene Name: | ATAD3A |
| Uniprot: | Q9NVI7 |
| Entrez: | 55210 |
Family
| Belongs to: |
|---|
| AAA ATPase family |
Alternative Names
ATPase family AAA domain-containing protein 3A; ATPase family, AAA domain containing 3A; FLJ10709; FLJ35514
Molecular Weight
Mass (kDA):
71.369 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.33 |
| Sequence: | 1; NC_000001.11 (1512143..1534687) |
Tissue Specificity
Overexpressed in lung adenocarcinomas (at protein level).
Subcellular Localizations
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion matrix, mitochondrion nucleoid. In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane (PubMed:20349121, PubMed:20154147). The N-terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids (PubMed:18063578).
Diseases
- Aortic Aneurysm, Abdominal
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Tumor Progression
- Optic Atrophy
- Uterine Cervical Neoplasm
- Mitochondrial Diseases
- Glioma
- Endometrial Polyp
- Human Papilloma Virus Infection
- Neoplasm Invasiveness
- Malignant Tumor Of Cervix
Pathways
- Localization
- Drug Resistance
- Cell Growth
- Transport
- Nucleoid Organization
- Gene Silencing
- Proteolysis
- Oxidative Phosphorylation
- Regeneration
- Translation
- Mitochondrial Nucleoid Organization
PTMs
Research Areas
- Protein Phosphatase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATAD3A
bosterbio.com/bosterbio-gene-info-cards/ATAD3A
References
PMID: 20332122 by Fang H.Y., et al. ATPase family AAA domain-containing 3A is a novel anti-apoptotic factor in lung adenocarcinoma cells.
PMID: 17210950 by He J., et al. The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization.