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- Table of Contents
ATP2A2 Antibodies
AND ATP2A2 ELISA kits, ATP2A2 Proteins
Many biological assays use antibodies to detect ATP2A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATP2A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATP2A2 antibodies...
Designing a Western blot for ATP2A2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ATP2A2 Western Blot GuideATP2A2 Infographic by Boster Bio
All ATP2A2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01176
100 μl
Cat # M01176
100 μl
ATP2A2 Overview
Facts about Sarcoplasmic/endoplasmic reticulum calcium ATPase 2.
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2)
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of this contraction/relaxation cycle (PubMed:16402920).
Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is vital for the TNFSF11- induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER contributes to cytosolic Ca (2+) spiking for activation of NFATC1 and generation of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | ATP2A2 |
| Uniprot: | P16615 |
| Entrez: | 488 |
Family
| Belongs to: |
|---|
| cation transport ATPase (P-type) (TC 3.A.3) family |
Alternative Names
ATP2BFLJ20293; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletalmuscle isoform; cardiac Ca2+ ATPase; DAR; DD; EC 3.6.3; EC 3.6.3.8; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; FLJ38063; MGC45367; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2DKFZp686P0211; SR Ca(2+)-ATPase 2
Molecular Weight
Mass (kDA):
114.757 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.11 |
| Sequence: | 12; NC_000012.12 (110281247..110351093) |
Tissue Specificity
Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart.
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Diseases
- Keratosis Follicularis
- Heart Failure
- Endometriosis, Site Unspecified
- Hypertrophy
- Cardiomyopathies
- Dermatologic Disorders
- Cardiac Hypertrophy
- Diabetes Mellitus
- Myocardial Infarction
- Infarction
- Acantholysis
- Tissue Adhesions
Interacting Proteins
- CFTR
- F2RL1
- OPRD1
Pathways
- Transport
- Keratinization
- Localization
- Pathogenesis
- Secretory Pathway
- Aging
- Cell Death
- Secretion
- Glycolysis
- Keratinocyte Differentiation
- Methylation
- Cell Growth
- Exocytosis
PTMs
- Phosphorylation
- Oxidation
- Methylation
- Dephosphorylation
- Nitration
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATP2A2
bosterbio.com/bosterbio-gene-info-cards/ATP2A2
References
PMID: 2844796 by Lytton J., et al. Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene.
PMID: 12659872 by Gelebart P., et al. Identification of a new SERCA2 splice variant regulated during monocytic differentiation.
1 Publications of Boster ATP2A2 Antibodies & ELISA Kits
- PubMed ID: 24324360, Guo Y, Zeng Qc, Zhang Cq, Zhang Xz, Li Rx, Wu Jm, Guan J, Liu L, Zhang Xc, Li Jy...
*More publications can be found for each product on its corresponding product page