ATP2A3 Antibodies

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3)

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen.

Contributes to calcium sequestration involved in muscle excitation/contraction. .

Gene Information

Human
Gene Name:	ATP2A3
Uniprot:	Q93084
Entrez:	489

Family

Belongs to:
cation transport ATPase (P-type) (TC 3.A.3) family

Alternative Names

adenosine triphosphatase, calcium; ATPase, Ca(2+)-transporting, ubiquitous; ATPase, Ca++ transporting, ubiquitous; Calcium pump 3; EC 3.6.3; EC 3.6.3.8; sarco/endoplasmic reticulum Ca2+ ATPase; sarco/endoplasmic reticulum Ca2+ -ATPase; sarcoplasmic/endoplasmic reticulum calcium ATPase 3; SERCA3calcium-translocating P-type ATPase; SR Ca(2+)-ATPase 3

Molecular Weight

Mass (kDA):
113.977 kDA

Genomic Context

Human
Location:	17p13.2
Sequence:	17; NC_000017.11 (3923869..3964464, complement)

Tissue Specificity

Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelial, or embryonic origin and also expressed in several cancer cell lines.

Subcellular Localizations

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

• Malignant Neoplasms
• Endometriosis, Site Unspecified
• Diabetes Mellitus
• Malignant Tumor Of Colon
• Carcinoma
• Colonic Neoplasms
• Malignant Squamous Cell Neoplasm
• Neoplasms
• Adenocarcinoma
• Heart Failure
• Diabetes Mellitus, Non-insulin-dependent
• Diabetes Mellitus, Insulin-dependent
• Dermatologic Disorders

• Keratosis Follicularis
• Head And Neck Carcinoma
• Cell Transformation, Neoplastic
• Hypertensive Disease
• Stomach Neoplasms
• Adenoma
• Adolescent Idiopathic Scoliosis

Pathways

• Secretion
• Transport
• Insulin Secretion
• Localization
• Cell Differentiation
• Proteolysis
• Translation
• Methylation
• Cell Death
• Platelet Maturation
• Cell Growth
• Regulation Of Insulin Secretion
• Pathogenesis

• Cell Adhesion
• Programmed Cell Death
• Aging
• Response To Biotin
• Platelet Aggregation
• Glucose Homeostasis
• Store-operated Calcium Entry

PTMs

• Phosphorylation

• Methylation

• Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATP2A3

Boster Bio - Best Uses Of The ATP2A3 Marker

Read on to learn more information about the ATP2A3 protein. This article will provide information about the ATP2A3 genes and enzymes, as well as their uses. This article will help explain how the marker works and how it affects cells. You can learn more about this gene, and the enzyme, whether you are a biologist or researcher.

ATP2A3 Author Marker

The ATP2A3 protein is a regulator element for Ca2+ transport. ATP2A3 is an important regulator for the transport of Ca2+. Its aberrant expression can increase the production of ER Stress biomarkers such as ATF4, Caspase 12 and phosphorylation PERK. Furthermore, the overexpression of ATP2A3 upregulated the phosphorylation of eIF2a. These results indicate that ATP2A3 is a potential target for salinomycin.

This protein is responsible in pumping Ca2+ to the ER of eukaryotic cellular cells. The survival of cancer depends on the ER stress biomarkers ATP2A3 & ER–Ca2+. This study has shown that salinomycin can inhibit the ATP2A3-protein by triggering ER Stress. This could explain the anticancer effects of salinomycin.

Information about ATP2A3 enzyme

The human genome contains the ATP2A3 enzyme. Its 17p13.2 position makes it conserved within chimpanzees (Rhesus monkeys), dogs (rats, chickens), and frogs. The enzyme has orthologs in 195 organisms. It transports energy to the cells and degrades glucose. ATP2A3 enzyme has been identified as a methyltransferase.

The ATP2A3 enzyme is a combination of an enzyme that catalyzes ATP hydrolysis and calcium transport from the cytosol. It is also involved in the calcium sequestration of muscle cells, which is important for muscle contraction and excitation. It is essential for the development and function, as well as muscle contraction and relaxation. Alternative splicing is used to produce ATP2A3.

ATP2A3 protein

Boster Bio ATP2A3 Protein - A rabbit polyclonal antibodies that has been validated for use in Immunohistochemistry or Western Blot. It reacts to ATP2A3 protein, and is cross-reactive for human, mouse, and rat cell. The antibody was designed specifically to recognize the protein. This product contains a recombinant ATP2A3 fusion Protein.

HIF4h2-KO mice express less ATP2A3 than the wild type. This mutant is missing the mRNA for HIF–P4H2 or SERCA2B but does not have any of these ATPases. The KO mice are more vulnerable to calcium signaling that normal cells. This protein helps maintain calcium homeostasis in the ER.

ATP2A3 is responsible for controlling V(D?J) recombination. A cell lacking in this protein results in a reduction of mature B cells. Humans with Darier disease have reduced numbers of mature B cells. SERCA proteins regulate intracellular Ca2+, RAG1 & RAG2 gene expression, V(D)J Recombination, and RAG1 & RAG2 gene transcription. Lympopenia can be caused by a defect in any of these functions.

P4HTM-TM KO cells show an increase in activity when they are treated with 100mm ATP. These cells release calcium when stimulated with 100 mmATP. The experiments were done on n=26 cells and six mice for each genotype. An ATPase kit was used to measure the ATPase activity. Its data are presented in the form of the mean of three different experiments.

ATP2A3 gene

The ATP2A3 gene encodes the sarcoplasmic/endoplasmic reticulum calcium ATPase 3, also known as SERCA3. This intracellular pump plays a role in calcium sequestration during muscle contraction. These are its best uses: