ATP2B4 Antibodies

AND ATP2B4 ELISA kits, ATP2B4 Proteins

Many biological assays use antibodies to detect ATP2B4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATP2B4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATP2B4 antibodies...

We validate the specificity of these antibodies to ATP2B4 by testing them on tissues known to express ATP2B4 positively and negatively. Browse below to find the ATP2B4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ATP2B4 Infographic by Boster Bio

All ATP2B4 Products

Product

Figures

Specificity

Applications

Price

ATP2B4 (NM_001684) Human Recombinant Protein

$1249
Cat # PROTP23634
20 µg

ATP2B4 (NM_001684) Human Over-expression Lysate

Human

$960
Cat # LS000493
100 µg

ATP2B4 Overview

Facts about Plasma membrane calcium-transporting ATPase 4.

ATP2B4 3D structure. Source: alphafold

Plasma membrane calcium-transporting ATPase 4 (ATP2B4)

Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity).

Gene Information

Human
Gene Name:	ATP2B4
Uniprot:	P23634
Entrez:	493

Family

Belongs to:

cation transport ATPase (P-type) (TC 3.A.3) family

Alternative Names

ATP2B2plasma membrane calcium ATPase; ATPase, Ca++ transporting, plasma membrane 4; DKFZp686G08106; DKFZp686M088; EC 3.6.3; EC 3.6.3.8; Matrix-remodeling-associated protein 1; matrix-remodelling associated 1; MXRA1; Plasma membrane calcium ATPase isoform 4; Plasma membrane calcium pump isoform 4; plasma membrane calcium pump; plasma membrane calcium-transporting ATPase 4; PMCA4b; PMCA4PMCA4x; sarcolemmal calcium pump

Molecular Weight

Mass (kDA):
137.92 kDA

Genomic Context


Human

Location:	1q32.1
Sequence:	1; NC_000001.11 (203626787..203744081)

Tissue Specificity

Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.

Diseases

Hypertensive Disease
Infertility
Diabetes Mellitus
Hypertrophy
Stenosis
Communicable Diseases
Anemia, Sickle Cell
Adolescent Idiopathic Scoliosis
Ataxia
Colonic Neoplasms
Neuromuscular Diseases
Cardiac Hypertrophy

Glaucoma, Open-angle
Malignant Tumor Of Colon
Malaria, Falciparum
Endoplasmic Reticulum Stress
Vascular Ring
Fibrosis

Interacting Proteins

CALCA
Dlg2
Dlg3

Pathways

Transport
Localization
Platelet Maturation
Sperm Motility
Vascular Smooth Muscle Contraction
Smooth Muscle Contraction
Proteolysis
Platelet Activation
Muscle Contraction
Spermatogenesis
Translation
Cell Cycle
Cell Death

Cell Differentiation
Cell Growth
Mating
Vasoconstriction
Pathogenesis
Mating Behavior
Regulation Of Blood Pressure

PTMs

Phosphorylation
Nitrosylation

Carboxylation
Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATP2B4

References

PMID: 2137451 by Strehler E.E., et al. Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane.

PMID: 1531651 by Brandt P., et al. Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels.