ATP synthase subunit f, mitochondrial (ATP5MF)

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or intricate V) generates ATP from ADP in the presence of a proton gradient across the membrane that's generated by electron transfer complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stem.

During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain.