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- Table of Contents
Facts about Renin receptor.
By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a part in the renin-angiotensin system (RAS). .
Human | |
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Gene Name: | ATP6AP2 |
Uniprot: | O75787 |
Entrez: | 10159 |
Belongs to: |
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No superfamily |
APT6M8-9; ATP6AP2; ATP6IP2; ATP6M8-9; ATP6M8-9MRXE; ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; ATPase, H+ transporting, lysosomal accessory protein 2; ATPase, H+ transporting, lysosomal interacting protein 2; CAPER; ELDF10; Embryonic liver differentiation factor 10; ER-localized type I transmembrane adaptor; H+ transporting, lysosomal (vacuolar proton pump) membrane sectorassociated protein M8-9; HT028; M8-9; MGC99577; MRXE; MSTP009; N14F; Renin R; renin receptor; ReninR; vacuolar proton ATP synthase membrane sector associa
Mass (kDA):
39.008 kDA
Human | |
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Location: | Xp11.4 |
Sequence: | X; NC_000023.11 (40580970..40606848) |
Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta.
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Lysosome membrane. Cytoplasmic vesicle, autophagosome membrane. Cell projection, dendritic spine membrane. Cell projection, axon.
PMID: 12045255 by Nguyen G., et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.
PMID: 9556572 by Ludwig J., et al. Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules.