V-type proton ATPase subunit G 1 (ATP6V1G1)

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the action of Fe(2+) prolyl hydroxylase (PHD) enzymes, and resulting in HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). .