ARHGEF12 Antibodies

AND ARHGEF12 ELISA kits, ARHGEF12 Proteins

Many biological assays use antibodies to detect ARHGEF12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARHGEF12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARHGEF12 antibodies...

We validate the specificity of these antibodies to ARHGEF12 by testing them on tissues known to express ARHGEF12 positively and negatively. Browse below to find the ARHGEF12 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for ARHGEF12? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the ARHGEF12 Western Blot Guide

Designing an IHC experiment for ARHGEF12? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the ARHGEF12 IHC Guide

ARHGEF12 Infographic by Boster Bio

All ARHGEF12 Products

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Product

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Specificity

Applications

Price

Anti-LARG/ARHGEF12 Antibody Picoband®

Western blot analysis of LARG/ARHGEF12 using anti-LARG/ARHGEF12 antibody (A06802-3)

IHC analysis of ARHGEF12L using anti-ARHGEF12L antibody (A06802-3)

Human, Mouse, Rat

ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # A06802-3
100 µg/vial

Anti-LARG/ARHGEF12 Antibody Picoband®

Western blot analysis of LARG/ARHGEF12 using anti-LARG/ARHGEF12 antibody (A06802-2)

Flow Cytometry analysis of HL-60 cells using anti-LARG/ARHGEF12 antibody (A06802-2)

Human, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A06802-2
100 μg/vial

ARHGEF12 Overview

Facts about Rho guanine nucleotide exchange factor 12.

ARHGEF12 3D structure. Source: alphafold

Rho guanine nucleotide exchange factor 12 (ARHGEF12)

May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and might act as GTPase-activating protein (GAP) for GNA12 and GNA13.

Gene Information

Human
Gene Name:	ARHGEF12
Uniprot:	Q9NZN5
Entrez:	23365

Family

Belongs to:

No superfamily

Alternative Names

ARHGC; ARHGEF12; DKFZp686O2372; KIAA0382PRO2792; LARG; LARGleukemia-associated rho guanine nucleotide exchange factor; Leukemia-associated RhoGEF; Rho guanine nucleotide exchange factor (GEF) 12; rho guanine nucleotide exchange factor 12

Molecular Weight

Mass (kDA):
173.232 kDA

Genomic Context


Human

Location:	11q23.3
Sequence:	11; NC_000011.10 (120336276..120489937)

Tissue Specificity

Ubiquitously expressed. Isoform 2 is found in jejunum and testis.

Subcellular Localizations

Cytoplasm. Membrane. Translocated to the membrane upon stimulation.

Diseases

Leukemia
Malignant Neoplasms
Myeloid Leukemia
Leukemia, Myelocytic, Acute
Tissue Adhesions
Neoplasms
Carcinoma
Nervousness
Cell Transformation, Neoplastic
Neoplasm Metastasis
Neoplasm Invasiveness
Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent

Prostatic Neoplasms
Cell Invasion
Malignant Neoplasm Of Prostate
Insulin Sensitivity
Hypertensive Disease
Congenital Muscular Dystrophy (disorder)
Urinary Bladder Diseases

Interacting Proteins

IGF1R
Lpar1
RHOA

Pathways

Localization
Transport
Cell Migration
Cell Motility
Axon Guidance
Cell Differentiation
Ion Transport
Cell Growth
Cell Adhesion
Cell Activation
Muscle Cell Differentiation
Cytokinesis
Nuclear Transport

Negative Regulation Of Cell Activation
Chemotaxis
Reverse Transcription
Cholesterol Efflux
Vasoconstriction
Smooth Muscle Cell Differentiation
Nuclear Import

PTMs

Phosphorylation
Biotinylation

Glycosylation
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARHGEF12

References

PMID: 10681437 by Kourlas P.J., et al. Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia.

PMID: 11094164 by Fukuhara S., et al. Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho.