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- Table of Contents
Facts about BRISC and BRCA1-A complex member 2.
In the BRCA1-A complicated, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the remainder of the complex, thereby needing the intricate integrity and regulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748). Part of the BRISC complicated, a multiprotein complex that specifically cleaves'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665).
Human | |
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Gene Name: | BABAM2 |
Uniprot: | Q9NXR7 |
Entrez: | 9577 |
Belongs to: |
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BABAM2 family |
brain and reproductive organ-expressed (TNFRSF1A modulator); BRCA1/BRCA2-containing complex subunit 45; subunit 4
Mass (kDA):
43.552 kDA
Human | |
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Location: | 2p23.2 |
Sequence: | 2; NC_000002.12 (27888709..28338901) |
Expressed in all cell lines examined. Highly expressed in placenta.
Cytoplasm. Nucleus. Localizes at sites of DNA damage at double-strand breaks (DSBs).
PMID: 7826398 by Li L., et al. Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid.
PMID: 11676476 by Ching A.K.K., et al. Expression of human BRE in multiple isoforms.