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- Table of Contents
Beta-secretase 1 Antibodies
AND BACE1 ELISA kits, Beta-secretase 1 Proteins
Many biological assays use antibodies to detect Beta-secretase 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Beta-secretase 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Beta-secretase 1 antibodies...
Designing a Western blot for Beta-secretase 1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the BACE1 Western Blot GuideBACE1 Infographic by Boster Bio
All BACE1 Products
Product
Figures
Specificity
Applications
Price
Anti-BACE1/Bace Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
IP, WB
$370
Cat # M00322
100 μl
Cat # M00322
100 μl
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00322-1
100 μg
Cat # M00322-1
100 μg
BACE1 Overview
Facts about Beta-secretase 1.
Beta-secretase 1 (BACE1)
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of this A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, along with a corresponding cell-associated C-terminal fragment that's later released by gamma-secretase.
Cleaves APP with much more catalytic efficiency than for the wild-type. .
Gene Information
| Human | |
|---|---|
| Gene Name: | BACE1 |
| Uniprot: | P56817 |
| Entrez: | 23621 |
Family
| Belongs to: |
|---|
| peptidase A1 family |
Alternative Names
APP beta-secretase; ASP2; Aspartyl protease 2; BACE1; BACE-1; BACEAsp 2; beta-secretase 1 precursor variant 1; beta-secretase 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; beta-site APP-cleaving enzyme; EC 3.4.23; EC 3.4.23.46; FLJ90568; HSPC104; KIAA1149; memapsin-2; Membrane-associated aspartic protease 2; transmembrane aspartic proteinase Asp2
Molecular Weight
Mass (kDA):
55.764 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.3 |
| Sequence: | 11; NC_000011.10 (117285207..117316256, complement) |
Tissue Specificity
Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane raft. Lysosome. Late endosome. Early endosome. Recycling endosome. Cell projection, axon. Cell projection, dendrite. Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (PubMed:17425515, PubMed:11466313). Colocalizatio
Diseases
- Alzheimer's Disease
- Plaque, Amyloid
- Senile Plaques
- Neuroblastoma
- Dental Plaque
- Neurodegenerative Disorders
- Nerve Degeneration
- Dementia
- Alzheimer Disease, Familial
- Neurofibrillary Tangles
- Nervousness
- Impaired Cognition
Interacting Proteins
- ADAM10
- APP
- Clec4g
- FLOT2
- GGA1
- GGA2
- GGA3
- IAPP
- ITM2B
- KCNC4
Pathways
- Pathogenesis
- Secretion
- Proteolysis
- Localization
- Transport
- Protein Processing
- Aging
- Cell Death
- Secretory Pathway
- Translation
- Endocytosis
- Glycosylation
- Rna Interference
PTMs
- Cleavage
- Phosphorylation
- Glycosylation
- Gamma-cleavage
- Biotinylation
- Ubiquitination
- Methylation
- Ribosylation
- Reduction
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BACE1
bosterbio.com/bosterbio-gene-info-cards/BACE1
References
PMID: 10531052 by Vassar R., et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
PMID: 10591214 by Sinha S., et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain.
4 Publications of Boster Beta-secretase 1 Antibodies & ELISA Kits
- PubMed ID: 10.3892/etm.2015.2391, Expression of β-site APP-cleaving enzyme 1 in the hippocampal tissue of an insu...
- PubMed ID: -, Ou Qiao,Xinyu Zhang,Yi Zhang et al.Cerebralcare Granule® enhances memantine hyd...
- PubMed ID: 32427716, Wu J,Qu JQ,Zhou YJ,Zhou YJ,Li YY,Huang NQ,Deng CM,Luo Y.Icariin improves cogniti...
- PubMed ID: 26136993, Expression of ?-site APP-cleaving enzyme 1 in the hippocampal tissue of an insul...
*More publications can be found for each product on its corresponding product page