BAG family molecular chaperone regulator 1 (BAG1)

Co-chaperone for HSP70 and HSC70 chaperone proteins.

Acts as a nucleotide-exchange variable (NEF) promoting the release of ADP in the HSP70 and HSC70 proteins thereby triggering client/substrate protein release.

Nucleotide release is mediated through its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated through its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and contains anti-apoptotic action (PubMed:12724406).