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- Table of Contents
BIN1 Antibodies
AND BIN1 ELISA kits, BIN1 Proteins
Many biological assays use antibodies to detect BIN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BIN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BIN1 antibodies...
Designing a Western blot for BIN1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the BIN1 Western Blot GuideDesigning an IHC experiment for BIN1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the BIN1 IHC GuideBIN1 Infographic by Boster Bio
All BIN1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01551-1
100 μg/vial
Cat # A01551-1
100 μg/vial
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01551-4
100 μl/vial
Cat # M01551-4
100 μl/vial
Human, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01551-3
100 μl/vial
Cat # M01551-3
100 μl/vial
BIN1 Overview
Facts about Myc box-dependent-interacting protein 1.
Myc box-dependent-interacting protein 1 (BIN1)
Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653).
Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792).
Gene Information
| Human | |
|---|---|
| Gene Name: | BIN1 |
| Uniprot: | O00499 |
| Entrez: | 274 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AMPH2; Amphiphysin II; Amphiphysin-like protein; AMPHLDKFZp547F068; box dependant MYC interacting protein 1; bridging integrator 1Box-dependent myc-interacting protein 1; MGC10367; myc box-dependent-interacting protein 1; SH3P9
Molecular Weight
Mass (kDA):
64.699 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q14.3 |
| Sequence: | 2; NC_000002.12 (127048023..127107154, complement) |
Tissue Specificity
Ubiquitous. Highest expression in the brain and muscle (PubMed:9182667). Expressed in oligodendrocytes (PubMed:27488240). Isoform IIA is expressed only in the brain, where it is detected in the gray matter, but not in the white matter (PubMed:27488240). Isoform BIN1 is widely expressed with highest expression in skeletal muscle.
Subcellular Localizations
[Isoform BIN1]: Nucleus. Cytoplasm. Endosome. Cell membrane, sarcolemma, T-tubule.; [Isoform IIA]: Cytoplasm.
Diseases
- Neoplasms
- Malignant Neoplasms
- Alzheimer's Disease
- Cell Transformation, Neoplastic
- Myopathy
- Congenital Structural Myopathy
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Weakness
- Mammary Neoplasms
- Carcinoma
- Congenital Myopathy (disorder)
- Dementia
Interacting Proteins
- BIN2
- DLGAP4
- FBP1
- MTM1
- MYC
- SNX4
- XRCC4
Pathways
- Endocytosis
- Localization
- Pathogenesis
- Cell Death
- Cell Proliferation
- Cell Cycle
- Dna Repair
- Programmed Cell Death
- Aging
- Methylation
- Cell Growth
- Dna Methylation
- Transport
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BIN1
bosterbio.com/bosterbio-gene-info-cards/BIN1
References
PMID: 9195986 by Ramjaun A.R., et al. Identification and characterization of a nerve terminal-enriched amphiphysin isoform.
PMID: 9182667 by Butler M.H., et al. Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of Ranvier in brain and around T tubules in skeletal muscle.