Birc6 Antibodies

AND Birc6 ELISA kits, Birc6 Proteins

Many biological assays use antibodies to detect Birc6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Birc6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Birc6 antibodies...

We validate the specificity of these antibodies to Birc6 by testing them on tissues known to express Birc6 positively and negatively. Browse below to find the Birc6 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Birc6? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the BIRC6 IHC Guide

Birc6 Infographic by Boster Bio

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Anti-BRUCE BIRC6 Antibody

Human

ELISA, IHC-P

$481
Cat # A01773
0.1 mg

Birc6 Overview

Facts about Baculoviral IAP repeat-containing protein 6.

Baculoviral IAP repeat-containing protein 6 (Birc6)

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase.

Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9.

Gene Information

Mouse
Gene Name:	Birc6
Uniprot:	O88738
Entrez:	12211

Family

Belongs to:

No superfamily

Alternative Names

APOLLON; baculoviral IAP repeat containing 6; baculoviral IAP repeat-containing 6; baculoviral IAP repeat-containing protein 6; BRUCE; FLJ13786; KIAA1289FLJ13726; Ubiquitin-conjugating BIR domain enzyme apollon; ubiquitin-conjugating BIR-domain enzyme apollon

Molecular Weight

Mass (kDA):
532.17 kDA

Genomic Context


Mouse

Location:	17\|17 E2
Sequence:	17;

Tissue Specificity

Widely expressed. Highly expressed in the brain and kidney.

Diseases

Malignant Neoplasms
Neoplasms
Leukemia
Leukemia, Myelocytic, Acute
Myeloid Leukemia
Cell Transformation, Neoplastic
Melanoma
Malignant Tumor Of Colon
Lymphoma
Adenocarcinoma
Childhood Acute Myeloid Leukemia
Colonic Neoplasms

Pancreatic Neoplasm
Colorectal Cancer
Malignant Neoplasm Of Pancreas
Neuroblastoma
Acute Lymphocytic Leukemia
Brain Neoplasms
Burkitt Lymphoma

Pathways

Cell Death
Cell Cycle
Rna Interference
Programmed Cell Death
Cell Proliferation
Cytokinesis
Cell Division
Oncogenesis
Induction Of Apoptosis
Conjugation
Localization
Drug Resistance
Cell Growth

Pathogenesis
Gene Silencing
Neutrophil Differentiation
Immune Response
Mitochondrial Depolarization
Cell Cycle Arrest
Embryo Development

PTMs

Cleavage

Ubiquitination

Research Areas

Apoptosis
Cancer
Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Birc6

References

PMID: 9628897 by Hauser H.P., et al. A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors.

PMID: 15485903 by Lotz K., et al. BRUCE, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network, is required for normal placenta development and mouse survival.