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Product Info Summary
| SKU: | A01773 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IHC-P |
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Product info
Product Name
Anti-BRUCE BIRC6 Antibody
SKU/Catalog Number
A01773
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-BRUCE BIRC6 Antibody (Catalog # A01773). Tested in ELISA, IHC-P applications. This antibody reacts with Human.
Storage & Handling
BRUCE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-BRUCE BIRC6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01773)
Host
Rabbit
Contents
BRUCE Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
BRUCE antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human BRUCE. The immunogen is located within amino acids 4760 - 4810 of BRUCE.
Cross-reactivity
BRUCE antibody is human specific. Multiple isoforms of BRUCE are known to exist.
Reactive Species
A01773 is reactive to BIRC6 in Human
Observed Molecular Weight
68 kDa
Calculated molecular weight
530.3 kDa
Background of BIRC6
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01773 is guaranteed for ELISA, IHC-P Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
BRUCE antibody can be used for detection of BRUCE by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Immunohistochemistry of BRUCE in human small intestine tissue with BRUCE antibody at 5 μg/mL.
Specific Publications For Anti-BRUCE BIRC6 Antibody (A01773)
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