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Anti-BRUCE BIRC6 Antibody
Boster Bio Anti-BRUCE BIRC6 Antibody (Catalog # A01773). Tested in ELISA, IHC-P applications. This antibody reacts with Human.
Storage & Handling
BRUCE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-BRUCE BIRC6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01773)
BRUCE Antibody is supplied in PBS containing 0.02% sodium azide.
BRUCE antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human BRUCE. The immunogen is located within amino acids 4760 - 4810 of BRUCE.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
BRUCE antibody is human specific. Multiple isoforms of BRUCE are known to exist.
A01773 is reactive to BIRC6 in Human
A01773 is guaranteed for ELISA, IHC-P Boster Guarantee
Background of BIRC6
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.
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Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.
BRUCE antibody can be used for detection of BRUCE by immunohistochemistry at 5 μg/mL. Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Validation Images & Assay Conditions
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Immunohistochemistry of BRUCE in human small intestine tissue with BRUCE antibody at 5 μg/mL.
Gene/Protein Information For BIRC6 (Source: Uniprot.org, NCBI)
Baculoviral IAP repeat-containing protein 6
APOLLON; baculoviral IAP repeat containing 6; baculoviral IAP repeat-containing 6; baculoviral IAP repeat-containing protein 6; BRUCE; FLJ13786; KIAA1289FLJ13726; Ubiquitin-conjugating BIR domain enzyme apollon; ubiquitin-conjugating BIR-domain enzyme apollon BIRC6 APOLLON, BRUCE baculoviral IAP repeat containing 6 baculoviral IAP repeat-containing protein 6|BIR repeat-containing ubiquitin-conjugating enzyme|RING-type E3 ubiquitin transferase BIRC6|ubiquitin-conjugating BIR-domain enzyme apollon*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".
For more info on BIRC6, check out the BIRC6 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for BIRC6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected]
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