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- Table of Contents
BTRC Antibodies
AND BTRC ELISA kits, BTRC Proteins
Many biological assays use antibodies to detect BTRC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BTRC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BTRC antibodies...
Designing a Western blot for BTRC? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the BTRC Western Blot GuideDesigning an IHC experiment for BTRC? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the BTRC IHC GuideBTRC Infographic by Boster Bio
All BTRC Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$540
Cat # EKC2339
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2339
1 kit, containing two 96-well plates and all necessary reagents
BTRC Overview
Facts about F-box/WD repeat-containing protein 1A.
F-box/WD repeat-containing protein 1A (BTRC)
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and likely NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14681206, PubMed:14603323).
SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169, PubMed:10644755). Ubiquitination of NFKBIA occurs at'Lys-21' and'Lys-22' (PubMed:10066435).
Gene Information
| Human | |
|---|---|
| Gene Name: | BTRC |
| Uniprot: | Q9Y297 |
| Entrez: | 8945 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
beta-transducin repeat containing; betaTrCP; BETA-TRCP; betaTrCP1; beta-TrCP1; BTRC; BTRCP; bTrCP1; E3RSIkappaB; F-box and WD repeats protein beta-TrCP; F-box/WD repeat-containing protein 1A; FBW1A; FBXW1; FBXW1A; FBXW1ABTRCP; FWD1; MGC4643; pIkappaBalpha-E3 receptor subunit
Molecular Weight
Mass (kDA):
68.867 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q24.32 |
| Sequence: | 10; NC_000010.11 (101353808..101557321) |
Tissue Specificity
Expressed in epididymis (at protein level).
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Carcinoma
- Hiv Infections
- Immunologic Deficiency Syndromes
- Tissue Adhesions
- Adenomatous Polyposis Coli
- Inflammation
- Polyposis
- Medulloblastoma
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- AMER1
- ATF4
- CEP68
- CTNNB1
- CUL1
- DLG1
- Dlg1
- GLI2
- IL10RA
- INAVA
Pathways
- Proteolysis
- Cell Cycle
- Pathogenesis
- Translation
- Mitosis
- Localization
- Cell Adhesion
- Anaphase
- Rna Interference
- S Phase
- Cell Cycle Arrest
- Metaphase
- Spindle Checkpoint
PTMs
- Phosphorylation
- Ubiquitination
Research Areas
- Signal Transduction
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BTRC
bosterbio.com/bosterbio-gene-info-cards/BTRC
References
PMID: 9859996 by Yaron A., et al. Identification of the receptor component of the IkappaBalpha- ubiquitin ligase.
PMID: 9660940 by Margottin F., et al. A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif.