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- Table of Contents
BUB3 Antibodies
AND BUB3 ELISA kits, BUB3 Proteins
Many biological assays use antibodies to detect BUB3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BUB3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BUB3 antibodies...
Designing a Western blot for BUB3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the BUB3 Western Blot GuideBUB3 Infographic by Boster Bio
All BUB3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M03118-1
100 μl/vial
Cat # M03118-1
100 μl/vial
BUB3 Overview
Facts about Mitotic checkpoint protein BUB3.
Mitotic checkpoint protein BUB3 (BUB3)
Has a double role in spindle-assembly checkpoint signaling and in promoting the establishment of proper kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments.
Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | BUB3 |
| Uniprot: | O43684 |
| Entrez: | 9184 |
Family
| Belongs to: |
|---|
| WD repeat BUB3 family |
Alternative Names
BUB3 (budding uninhibited by benzimidazoles 3, yeast) homolog; BUB3 budding uninhibited by benzimidazoles 3 homolog; Bub3; BUB3L; budding uninhibited by benomyl; budding uninhibited by benzimidazoles 3 homolog (yeast); hBUB3; mitotic checkpoint component; mitotic checkpoint protein BUB3
Molecular Weight
Mass (kDA):
37.155 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q26.13 |
| Sequence: | 10; NC_000010.11 (123154244..123170467) |
Subcellular Localizations
Nucleus. Chromosome, centromere, kinetochore. Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition.
Diseases
- Malignant Neoplasms
- Neoplasms
- Aneuploidy
- Carcinoma
- Cell Transformation, Neoplastic
- Instabilities, Chromosomal
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Genomic Instability
- Polyploidy
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Lung
- Cytogenetic Abnormality
Interacting Proteins
- BUB1
- BUB1B
- PSTPIP1
Pathways
- Anaphase
- Spindle Checkpoint
- Mitosis
- Spindle Assembly
- Spindle Assembly Checkpoint
- Cell Cycle
- Chromosome Segregation
- Metaphase
- Localization
- Kinetochore Localization
- Cell Division
- Interphase
- Meiosis
PTMs
- Phosphorylation
- Ubiquitination
Research Areas
- Cell Cycle and Replication
- Core ESC-Like Genes
- DNA Repair
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BUB3
bosterbio.com/bosterbio-gene-info-cards/BUB3
References
PMID: 10198256 by Seeley T.W., et al. Phosphorylation of human MAD1 by the BUB1 kinase in vitro.
PMID: 9660858 by Taylor S.S., et al. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase.