C7 Infographic
Complement component C7 Info At a glance, species: Human
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Complement component C7 (C7)
Constituent of the membrane attack complex (MAC) that plays an integral role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 functions as a membrane anchor.
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Gene Information
| Human | |
|---|---|
| Gene Name: | C7 |
| Uniprot: | P10643 |
| Entrez: | 730 |
Family
| Belongs to: |
|---|
| complement C6/C7/C8/C9 family |
Alternative Names
complement component 7; complement component C7
Molecular Weight
Mass (kDA):
93.518 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5p13.1 |
| Sequence: | 5; NC_000005.10 (40909497..40984643) |
Subcellular Localizations
Secreted.
Diseases
- Pain
- Spinal Cord Injuries
- Neoplasms
- Spinal Cord Diseases
- Flexed Fetal Attitude
- Fracture
- Compression Of Spinal Cord
- Neck Pain
- Radiculopathy
- Lordosis
- Quadriplegia
- Acquired Kyphosis
- Avulsed Wound
Pathways
- Complement Activation
- Transport
- Regeneration
- Translation
- Reflex
- Ossification
- Localization
- Innervation
- Pathogenesis
- Secretion
- Cell Death
- Hypersensitivity
- Immune Response
PTMs
- Cleavage
- Oxidation
- Acetylation
- Phosphorylation
- Hydroxylation
- Reduction
- Methylation
- Glycosylation
- Carboxylation
- Amidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/C7
bosterbio.com/bosterbio-gene-info-cards/C7
References
PMID: 3335508 by Discipio R.G., et al. The structure of human complement component C7 and the C5b-7 complex.
PMID: 7730625 by Hobart M.J., et al. Structure of the human C7 gene and comparison with the C6, C8A, C8B and C9 genes.
