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- Table of Contents
Facts about Caspase recruitment domain-containing protein 9.
monocytogenes. Likely controls various innate immune response pathways depending on the intracellular pathogen.
Human | |
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Gene Name: | CARD9 |
Uniprot: | Q9H257 |
Entrez: | 64170 |
Belongs to: |
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No superfamily |
CANDF2; CARD9; caspase recruitment domain family, member 9; caspase recruitment domain-containing protein 9; hCARD9
Mass (kDA):
62.241 kDA
Human | |
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Location: | 9q34.3 |
Sequence: | 9; NC_000009.12 (136363956..136373669, complement) |
Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood leukocytes and in brain.
Cytoplasm.
You might be interested in purchasing the Boster Bio Anti-CARD9 marker, but you're not sure how best to use it. This article will provide information on how this marker can be used to perform immunofluorescence, ICC and gene infographics. Learn how to use this antibody to increase your research results. We will also go over how to optimize your experiments to achieve the best results.
Boster Bio Anti-CARD9 markers are high-affinity primary as well as ELISA kits. Researchers trust Boster antibodies, which are frequently referenced in the literature. Boster antibodies have been validated in Immunohistochemistry, Western Blotting, and ELISA. They are used in research to measure the levels of a wide range of proteins such as the IL-1b.
The CARD9 gene regulates chemokine production. It regulates the production of these chemicals in response to pro-inflammatory signals. It is also a potential therapeutic target. The following gene informationgraphics are available for the CARD9 marker:
The CARD9 gene is believed to be involved in a variety of conditions, including cancer, heart disease and aging, as per molecular evidence. The gene plays an important role in the secretion and production of chemokines Cytokines, and ROS in various cells and organs. The presence of genetic polymorphisms within this gene has been linked to an increase in the incidence of infectious diseases, CVDs, tumor formation and other health issues.
Boster Bio Anti CARD9 Antibody is a monoclonal purified antibody that is infused with 0.09 percent sodium azide. It was developed by using a mouse that had been immunized with human CARD9 recombinant protein. A blocking peptide can be used to block the antigen. It can be used to determine whether an antigen is specific or non-specific and to determine the most effective antibody for a particular use.
The CARD9 gene is a transcription factor that is responsible for attracting neutrophils into the body, is referred to as CARD9. These cells possess a powerful anti-fungal activity and are vital to protect the body from a variety of illnesses. This gene is likely to have a multitude of applications in the body. Below are a few promising uses for this gene. Read on for more details. Here are a few of the most important applications of the CARD9 gene.
The CARD9 gene plays a key role in the regulation of the production of cytokines as well as chemical mediators in response to pro-inflammatory signals. Inflammatory bowel diseases (IBDs) are a category of diseases that are characterized by chronic inflammation. CARD9 has been demonstrated to be linked with IBD in at least one subtype of GWAS studies. The variants associated with increased risk of IBD increase the production of NF-kB-mediated cytokine. The variant with protection is not equipped with the C-terminal functional domain, that is necessary for the recruitment of TRIM62 and ubiquitination of CARD9.
The CARD9 gene encodes the protein that is expressed by various types of cells. It is involved in the production of cytokines and Chemokines, adaptive immune, and autophagy. While it isn't clear exactly what the role CARD9 plays in these processes, it is believed that it could be involved as a catalyst for the development of various diseases. By understanding its role in these conditions and preventing them from progressing, we can better manage these diseases.
The CARD9 gene is critical for the development and progress of autoimmune uveitis. The CARD9 gene stimulates the development of Th27 and Th2-related responses in the EAU. Deficient mice in CARD9 also exhibit a lower severity of disease. However when it comes to inflammatory bowel diseases, an increased number of neutrophil-mediated inflammation could be responsible for the progression of the disease.
PMID: 11053425 by Bertin J., et al. CARD9 is a novel caspase recruitment domain-containing protein that interacts with Bcl10/CLAP and activates NF-kappa B.
PMID: 19864672 by Glocker E.-O., et al. A homozygous CARD9 mutation in a family with susceptibility to fungal infections.