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- Table of Contents
Facts about Peripheral plasma membrane protein CASK.
Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.
| Human | |
|---|---|
| Gene Name: | CASK |
| Uniprot: | O14936 |
| Entrez: | 8573 |

| Belongs to: |
|---|
| MAGUK family |

calcium/calmodulin-dependent serine protein kinase (MAGUK family); calcium/calmodulin-dependent serine protein kinase membrane-associatedguanylate kinase; Calcium/calmodulin-dependent serine protein kinase; CAMGUK; CMG; EC 2.7.11; EC 2.7.11.1; FGS4CAGH39; FLJ22219; hCASK; LIN2FLJ31914; MICPCH; peripheral plasma membrane protein CASK; Protein lin-2 homolog; TNRC8; trinucleotide repeat containing 8
Mass (kDA):
105.123 kDA

| Human | |
|---|---|
| Location: | Xp11.4 |
| Sequence: | X; NC_000023.11 (41514934..41923554, complement) |
Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver.
Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.






PMID: 9660868 by Cohen A.R., et al. Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells.
PMID: 11003712 by Stevenson D., et al. Mapping and expression analysis of the human CASK gene.