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- Table of Contents
CASK Antibodies
AND CASK ELISA kits, CASK Proteins
Many biological assays use antibodies to detect CASK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CASK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CASK antibodies...
Designing a Western blot for CASK? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CASK Western Blot GuideCASK Infographic by Boster Bio
All CASK Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A02468-2
100 μg/vial
Cat # A02468-2
100 μg/vial
CASK Overview
Facts about Peripheral plasma membrane protein CASK.
Peripheral plasma membrane protein CASK (CASK)
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1.
Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.
Gene Information
| Human | |
|---|---|
| Gene Name: | CASK |
| Uniprot: | O14936 |
| Entrez: | 8573 |
Family
| Belongs to: |
|---|
| MAGUK family |
Alternative Names
calcium/calmodulin-dependent serine protein kinase (MAGUK family); calcium/calmodulin-dependent serine protein kinase membrane-associatedguanylate kinase; Calcium/calmodulin-dependent serine protein kinase; CAMGUK; CMG; EC 2.7.11; EC 2.7.11.1; FGS4CAGH39; FLJ22219; hCASK; LIN2FLJ31914; MICPCH; peripheral plasma membrane protein CASK; Protein lin-2 homolog; TNRC8; trinucleotide repeat containing 8
Molecular Weight
Mass (kDA):
105.123 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp11.4 |
| Sequence: | X; NC_000023.11 (41514934..41923554, complement) |
Tissue Specificity
Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver.
Subcellular Localizations
Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.
Diseases
- Tissue Adhesions
- Nervousness
- Microcephaly
- Hypoplasia
- Congenital Cerebellar Hypoplasia
- Neoplasms
- Parkinson Disease
- Optic Atrophy
- Cleft Palate
- Atrophy
- Autistic Disorder
- Congenital Anomaly Of Brain
Interacting Proteins
- CASKIN1
- EPS8
- ID1
- LIN7A
- Nrxn1
- RPH3A
- SDC2
- SH2D4A
- SNTB2
Pathways
- Localization
- Transport
- Synaptic Transmission
- Cell Adhesion
- Cell Proliferation
- Brain Development
- Exocytosis
- Protein Targeting
- Pathogenesis
- Synaptic Vesicle Exocytosis
- Rna Interference
- Nucleosome Assembly
- Aging
PTMs
- Phosphorylation
- Glycosylation
- Sumoylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASK
bosterbio.com/bosterbio-gene-info-cards/CASK
References
PMID: 9660868 by Cohen A.R., et al. Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells.
PMID: 11003712 by Stevenson D., et al. Mapping and expression analysis of the human CASK gene.