Caspase-8 Antibodies

Caspase-8 (CASP8)

Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation.

The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC.

Gene Information

Human
Gene Name:	CASP8
Uniprot:	Q14790
Entrez:	841

Family

Belongs to:
peptidase C14A family

Alternative Names

AIS; androgen receptor; CASP8; Caspase8; Caspase-8; DHTRTFM; Dihydrotestosterone receptorHYSP1; HUMARA; Mch5; NR3C4KD; Nuclear receptor subfamily 3 group C member 4; SMAX1SBMA; spinal and bulbar muscular atrophy

Molecular Weight

Mass (kDA):
55.391 kDA

Genomic Context

Human
Location:	2q33.1
Sequence:	2; NC_000002.12 (201233443..201287711)

Tissue Specificity

Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle.

Subcellular Localizations

Cytoplasm.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Leukemia
• Mammary Neoplasms
• Malignant Neoplasm Of Breast
• Malignant Paraganglionic Neoplasm
• Inflammation
• Neuroblastoma
• Lymphoma
• Malignant Tumor Of Colon
• Adenocarcinoma
• Prostatic Neoplasms

• Liver Carcinoma
• Colonic Neoplasms
• Lung Neoplasms
• Malignant Neoplasm Of Prostate
• Cell Transformation, Neoplastic
• Malignant Neoplasm Of Lung
• Glioma

Interacting Proteins

• AR
• BCAP31
• CASP10
• CASP8AP2
• CFLAR

• CUL3
• FADD
• FAS
• FASLG
• ILK

• MALT1
• NOL3
• PTPN6
• RIPK1
• RNF34

• TNFAIP3
• TNFRSF10A

Pathways

• Cell Death
• Induction Of Apoptosis
• Cell Cycle
• Pathogenesis
• Programmed Cell Death
• Cell Proliferation
• Methylation
• Sensitization
• Cell Growth
• Localization
• Release Of Cytochrome C From Mitochondria
• Apoptotic Process
• Proteolysis

• Cell Cycle Arrest
• Secretion
• Immune Response
• Dna Methylation
• Cell Killing
• Dna Repair
• Rna Interference

PTMs

• Cleavage
• Phosphorylation
• Methylation
• Dephosphorylation
• Demethylation
• Acetylation
• Ubiquitination
• Reduction
• Oxidation
• Nitrosylation

• Biotinylation
• Myristoylation
• Ribosylation
• Sumoylation
• Phosphorothioation
• Prenylation
• Acylation
• Farnesylation
• Glycosylation
• Deacetylation

Research Areas

• Apoptosis
• Apoptosis Detections
• Cancer
• Caspases
• Cell Biology

• Phospho-Specific
• Ubiquitin Proteasome Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASP8

The Boster Bio: Best Uses Of The CASP8 Marker

The Boster Bio: Best Uses Of The Certified CASP8 Marker is an online resource for scientists to submit results for specific species or applications. Boster scientists can even receive product credits. These credits are applicable for scientists all over the world. Boster has a rich history that will make your research more efficient. We've gathered a few of his most valuable tips below.

Resources

Currently, scientists are trying to figure out whether CASP8 is a biomarker of high-risk prostate cancer. The protein is upregulated in prostate cancer and other cancers, and its high levels correlate with a higher risk of recurrence and progression. However, there is a lot of research to be done before this biomarker becomes a definitive biomarker of high-risk disease.

This cancer-specific protein plays a key role in apoptosis and necroptosis. It induces cytokine production and participates in TRAIL-induced inflammatory signaling. Furthermore, inhibiting CASP8 and its associated RING protein is known to suppress cancer growth. Some studies have shown that genetic variations in the CASP8 gene promoter may contribute to the development and progression of several types of cancer. In addition, circulating CASP8 is associated with esophageal squamous cell carcinoma risk.

PDFs

The Boster bio company was founded in 1993 and specializes in the manufacturing of antibody and ELISA products. In addition to antibodies, Boster offers PCR-related molecular biology products. Boster provides customers with technical support that is available 24 hours a day and provides free educational resources. Read on for more information about this company and their products. They have a variety of services to suit the needs of scientists of all levels and types.

Boster Bio provides a step-by-step IHC protocol that includes recommended reagents. Boster Bio also offers detailed step-by-step instructions for sample preparation. These guides can be used to optimize experiments and produce better results. Most researchers encounter trouble with their experiments, but proper controls and troubleshooting will eliminate many of the sources of error. Listed below are some tips for minimizing the impact of these problems.

Steven Boster's history

If you are interested in finding out more about Steve Boster, you have come to the right place. We have compiled public records about Steve, including his current and past home addresses, email addresses, and known relatives. If you want to know more about Steve, you can filter the records based on age, gender, and state. In this article, we've compiled a list of Steve's most notable achievements.