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- Table of Contents
Caspase-8 Antibodies
AND CASP8 ELISA kits, Caspase-8 Proteins
Many biological assays use antibodies to detect Caspase-8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Caspase-8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Caspase-8 antibodies...
Designing a Western blot for Caspase-8? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CASP8 Western Blot GuideCASP8 Infographic by Boster Bio
All CASP8 Products
Product
Figures
Specificity
Applications
Price
Anti-Caspase 8/CASP8 Antibody Picoband®
38 Citations
Human, Mouse, Rat
Flow Cytometry, IHC, IHC-F, ICC, WB
$370
Cat # A00042
100 μg/vial
Cat # A00042
100 μg/vial
Human Caspase 8/CASP8 ELISA Kit PicoKine®
2 Citations
Human
ELISA
$750
Cat # EK1426
96 wells/kit, with removable strips.
Cat # EK1426
96 wells/kit, with removable strips.
Anti-Caspase-8/CASP8 Antibody Picoband®
8 Citations
Human
ELISA, Flow Cytometry, WB
$370
Cat # A00042-3
100 μg/vial
Cat # A00042-3
100 μg/vial
Anti-Caspase-8 (P18)/CASP8 Antibody Picoband®
6 Citations
Human, Mouse, Rat
WB
$370
Cat # PA1308
100 μg/vial
Cat # PA1308
100 μg/vial
Human, Mouse, Rat
ELISA, IHC, WB
$370
Cat # A01295-1
100 μg/vial
Cat # A01295-1
100 μg/vial
Anti-Caspase 8/CASP8 Antibody Picoband®
2 Citations
Human, Mouse, Rat
ELISA, WB
$370
Cat # A00042-1
100 μg/vial
Cat # A00042-1
100 μg/vial
Anti-Caspase-8/CASP8 Antibody Picoband®
1 Citations
Human
Flow Cytometry, WB
$370
Cat # A00042-2
100 μg/vial
Cat # A00042-2
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00042-1
100 μl
Cat # M00042-1
100 μl
Human, Mouse, Rat
ELISA, IF, IHC-P, ICC, WB
$481
Cat # A00042-4
0.1 mg
Cat # A00042-4
0.1 mg
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC-P, ICC, WB
$481
Cat # A01295-2
0.1 mg
Cat # A01295-2
0.1 mg
Human, Mouse, Rat
ELISA, WB
$380
Cat # A00042S217
100ul
Cat # A00042S217
100ul
Human, Rat
ELISA
$540
Cat # EKC1976
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1976
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1088
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1088
1 kit, containing one 96-well plate and all necessary reagents
CASP8 Overview
Facts about Caspase-8.
Caspase-8 (CASP8)
Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation.
The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC.
Gene Information
| Human | |
|---|---|
| Gene Name: | CASP8 |
| Uniprot: | Q14790 |
| Entrez: | 841 |
Family
| Belongs to: |
|---|
| peptidase C14A family |
Alternative Names
AIS; androgen receptor; CASP8; Caspase8; Caspase-8; DHTRTFM; Dihydrotestosterone receptorHYSP1; HUMARA; Mch5; NR3C4KD; Nuclear receptor subfamily 3 group C member 4; SMAX1SBMA; spinal and bulbar muscular atrophy
Molecular Weight
Mass (kDA):
55.391 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q33.1 |
| Sequence: | 2; NC_000002.12 (201233443..201287711) |
Tissue Specificity
Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle.
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Leukemia
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Malignant Paraganglionic Neoplasm
- Inflammation
- Neuroblastoma
- Lymphoma
- Malignant Tumor Of Colon
- Adenocarcinoma
- Prostatic Neoplasms
Interacting Proteins
- AR
- BCAP31
- CASP10
- CASP8AP2
- CFLAR
- CUL3
- FADD
- FAS
- FASLG
- ILK
Pathways
- Cell Death
- Induction Of Apoptosis
- Cell Cycle
- Pathogenesis
- Programmed Cell Death
- Cell Proliferation
- Methylation
- Sensitization
- Cell Growth
- Localization
- Release Of Cytochrome C From Mitochondria
- Apoptotic Process
- Proteolysis
PTMs
- Cleavage
- Phosphorylation
- Methylation
- Dephosphorylation
- Demethylation
- Acetylation
- Ubiquitination
- Reduction
- Oxidation
- Nitrosylation
Research Areas
- Apoptosis
- Apoptosis Detections
- Cancer
- Caspases
- Cell Biology
- Phospho-Specific
- Ubiquitin Proteasome Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASP8
bosterbio.com/bosterbio-gene-info-cards/CASP8
References
PMID: 8681376 by Boldin M.P., et al. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.
PMID: 8681377 by Muzio M., et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex.
43 Publications of Boster Caspase-8 Antibodies & ELISA Kits
- PubMed ID: PMID:28559975, Inhibition of glioblastoma growth and invasion by 125I brachytherapy in rat glio...
- PubMed ID: 10.3892/or.2017.5395, Calcium release induced by 2-pyridinecarboxaldehyde thiosemicarbazone and its co...
- PubMed ID: 10.3892/or.2015.4530, Redox cycling of a copper complex with benzaldehyde nitrogen mustard-2-pyridine ...
- PubMed ID: 10.3892/ijo.2017.4149, Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate part...
- PubMed ID: 10.3892/ijo.2017.4148, Effects of baicalein on proliferation, apoptosis, migration and invasion of Ewin...
- PubMed ID: 10.3892/ijo.2015.3039, Autophagy is involved in recombinant Newcastle disease virus (rL-RVG)-induced ce...
- PubMed ID: 10.1248/bpb.b13-00794, Involvement of substance P/neurokinin-1 receptor in the analgesic and anticancer...
- PubMed ID: 10.1186/s12985-017-0852-z, Recombinant Newcastle disease virus rL-RVG enhances the apoptosis and inhibits t...
- PubMed ID: 10.1177/1934578X1200700826, Muscone Exerts Neuroprotection in an Experimental Model of Stroke via Inhibition...
- PubMed ID: 10.1155/2021/5594059, Ferritinophagy-Mediated ROS Production Contributed to Proliferation Inhibition, ...
- PubMed ID: 10.1142/S0192415X15500299, Apocynum venetum Attenuates Acetaminophen-Induced Liver Injury in Mice
- PubMed ID: 10.1111/dth.14720, CD4+T cells apoptosis and conversion of Th1/Th2‐type cytokines promote the pro...
- PubMed ID: 10.1039/C5TB00514K, Design of magnetic nanoparticles for hepatocellular carcinoma treatment using th...
- PubMed ID: 10.1038/aja.2009.87, Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in ...
- PubMed ID: 10.1016/j.toxicon.2009.01.035, Involvement of Fas/FasL system in apoptotic signaling in testicular germ cells o...
- PubMed ID: 10.1016/j.tiv.2007.04.008, A cytotoxin isolated from Agkistrodon acutus snake venom induces apoptosis via F...
- PubMed ID: 10.1016/j.taap.2010.02.004, The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is ...
- PubMed ID: 10.1016/j.jep.2008.10.042, Total saponins of Panax Notoginseng modulate the expression of caspases and atte...
- PubMed ID: 10.1016/j.bbrc.2005.03.182, Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human...
- PubMed ID: , Pathway of programmed cell death in HeLa cells induced by polymeric anti-cancer ...
- PubMed ID: , Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobil...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page