E3 ubiquitin-protein ligase CBL (CBL)

Adapter protein that acts as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Recognizes activated receptor tyrosine kinases, such as KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling.

Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells.