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- Table of Contents
CBL Antibodies
AND CBL ELISA kits, CBL Proteins
Many biological assays use antibodies to detect CBL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CBL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CBL antibodies...
Designing a Western blot for CBL? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CBL Western Blot GuideCBL Infographic by Boster Bio
All CBL Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9077
100 μg/vial
Cat # PB9077
100 μg/vial
Human, Mouse
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00038-1
100 µg/vial
Cat # A00038-1
100 µg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00152-2
100 μg/vial
Cat # A00152-2
100 μg/vial
Human, Mouse, Rat
WB
$370
Cat # P00152-1
100 μl/vial
Cat # P00152-1
100 μl/vial
Human
Flow Cytometry, IHC, WB
$370
Cat # P00152
100 μl/vial
Cat # P00152
100 μl/vial
![Western blot using Boster's Affinity Purified Anti-Hif3A antibody shows detection of a band ~72 kDa corresponding to mouse Hif3A [arrowhead]](/media/catalog/product/a/0/a03805-1-hif3a-primary-antibodies-wb-testing-1.jpg)
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$380
Cat # M00152
100ul
Cat # M00152
100ul
Human
Flow Cytometry, WB
$523
Cat # M03693
100 µl
Cat # M03693
100 µl
Human, Mouse, Rat
ELISA
$540
Cat # EKC2061
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2061
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2060
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2060
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2059
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2059
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1095
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1095
1 kit, containing one 96-well plate and all necessary reagents
Human
$628
Cat # LS000869
20 µg, 100 µg
Cat # LS000869
20 µg, 100 µg
Human
$628
Cat # LS002694
20 µg, 100 µg
Cat # LS002694
20 µg, 100 µg
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00735-1
100 μl/vial
Cat # A00735-1
100 μl/vial
Human
Cell Culture
$77
Cat # PROTP27352-1
5ug,20ug,100ug
Cat # PROTP27352-1
5ug,20ug,100ug
CBL Overview
Facts about E3 ubiquitin-protein ligase CBL.
E3 ubiquitin-protein ligase CBL (CBL)
Adapter protein that acts as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Recognizes activated receptor tyrosine kinases, such as KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling.
Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | CBL |
| Uniprot: | P22681 |
| Entrez: | 867 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma proto-oncogene; CBL; CBL2; CBL2E3 ubiquitin-protein ligase CBL; EC 6.3.2; EC 6.3.2.-; oncogene CBL2; Proto-oncogene c-Cbl; RING finger protein 55; RNF55; RNF55C-CBL; Signal transduction protein CBL
Molecular Weight
Mass (kDA):
99.633 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.3 |
| Sequence: | 11; NC_000011.10 (119206339..119308149) |
Subcellular Localizations
Cytoplasm. Cell membrane. Cell projection, cilium. Golgi apparatus. Colocalizes with FGFR2 in lipid rafts at the cell membrane.
Diseases
- Leukemia
- Malignant Neoplasms
- Neoplasms
- Vitamin B 12 Deficiency
- Cell Transformation, Neoplastic
- Myeloid Leukemia
- Lymphoma
- Tissue Adhesions
- Anemia
- Leukemia, Myelocytic, Acute
- Methylmalonic Acidemia
- Myeloid Leukemia, Chronic
Interacting Proteins
- ARHGEF7
- CD2AP
- CRK
- CRKL
- EGFR
- F2RL1
- FLT1
- Fyn
- GRB2
- ITSN1
Pathways
- Endocytosis
- Transport
- Pathogenesis
- Localization
- Cell Proliferation
- Cell Growth
- Cell Activation
- Secretion
- Cell Adhesion
- T Cell Activation
- Cell Death
- Receptor Internalization
- Glucose Transport
PTMs
- Phosphorylation
- Ubiquitination
- Dephosphorylation
- Cleavage
- Reduction
- Glycosylation
- Methylation
- Oxidation
- Myristoylation
- Biotinylation
Research Areas
- Cancer
- Signal Transduction
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CBL
bosterbio.com/bosterbio-gene-info-cards/CBL
References
PMID: 2030914 by Blake T.J., et al. The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.
PMID: 10092522 by Howlett C.J., et al. The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.