CCM2 Antibodies

AND CCM2 ELISA kits, CCM2 Proteins

Many biological assays use antibodies to detect CCM2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CCM2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CCM2 antibodies...

We validate the specificity of these antibodies to CCM2 by testing them on tissues known to express CCM2 positively and negatively. Browse below to find the CCM2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for CCM2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the CCM2 IHC Guide

CCM2 Infographic by Boster Bio

All CCM2 Products

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Product

Figures

Specificity

Applications

Price

Anti-CCM2 Antibody

Western blot analysis of extracts of MCF7 cells, using CCM2 antibody at 1:1000 dilution

Immunohistochemistry of paraffin-embedded human liver using CCM2 antibody at dilution of 1:100

Immunohistochemistry of paraffin-embedded rat heart using CCM2 antibody at dilution of 1:100

Human, Mouse, Rat

IHC, WB

$405
Cat # A01908
100ul

CCM2 (NM_001029835) Human Over-expression Lysate

CCM2 Human Over-expression Lysates NM_001029835

Human

$960
Cat # LS083605
20 µg, 100 µg

C20orf160 (CCM2L) (NM_080625) Human Over-expression Lysate

Human

$628
Cat # LS140706
20 µg, 100 µg

CCM2 (NM_031443) Human Recombinant Protein

Coomassie blue staining of purified CCM2 protein

$1249
Cat # PROTQ9BSQ5
20 µg

CCM2 Overview

Facts about Cerebral cavernous malformations 2 protein.

CCM2 3D structure. Source: alphafold

Cerebral cavernous malformations 2 protein (CCM2)

Part of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act via the insertion of endothelial cell junctions (By similarity).

May serve as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a significant role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock (By similarity).

Gene Information

Human
Gene Name:	CCM2
Uniprot:	Q9BSQ5
Entrez:	83605

Family

Belongs to:

CCM2 family

Alternative Names

C7orf22OSM; cerebral cavernous malformation 2; Cerebral cavernous malformations 2 protein; chromosome 7 open reading frame 22; malcavernin; MGC4067; MGC4607; MGC74868

Molecular Weight

Mass (kDA):
48.837 kDA

Genomic Context


Human

Location:	7p13
Sequence:	7; NC_000007.14 (44999746..45076470)

Subcellular Localizations

Cytoplasm.

Diseases

Cavernous Hemangioma Of Brain
Hemangioma, Cavernous, Central Nervous System
Vascular Anomaly
Nervousness
Cerebrovascular Accident
Hemorrhage
Headache
Brain Hemorrhage
Central Nervous System Vascular Malformations
Tumor Angiogenesis
Intracranial Arteriovenous Malformation
Brain Neoplasms

Congenital Vascular Anomaly
Cerebral Hemorrhage
Pathologic Neovascularization
Central Nervous System Neoplasms
Neoplasms
Vascular Diseases
Hemangioma, Cavernous

Interacting Proteins

DOK4
KRIT1
MAP3K3
PDCD10
TWIST2

VSTM2L

Pathways

Pathogenesis
Cell Death
Angiogenesis
Programmed Cell Death
Localization
Vasculogenesis
Cell Migration
Tube Formation
Brain Development
Spermatogenesis
Cell Proliferation
Cell Adhesion
Gene Silencing

Fertilization
Endothelial Cell Proliferation
Nuclear Export
Mesenchymal Cell Differentiation
Cell Differentiation
Wound Healing
Cell Morphogenesis

PTMs

Phosphorylation

Cleavage

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCM2

References

PMID: 14624391 by Liquori C.L., et al. Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations.

PMID: 20489202 by Li X., et al. Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity.