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1 Citations 6 Q&As
Facts about CCN family member 1.
CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1.
Human | |
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Gene Name: | CCN1 |
Uniprot: | O00622 |
Entrez: | 3491 |
Belongs to: |
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CCN family |
CCN family member 1; CCN1; CCN1IGF-binding protein 10; Cyr61; Cysteine-rich angiogenic inducer 61; cysteine-rich, angiogenic inducer, 61; GIG1; GIG1cysteine-rich heparin-binding protein 61; IBP-10; IGFBP-10; IGFBP10cysteine-rich, anigogenic inducer, 61; Insulin-like growth factor-binding protein 10; protein CYR61; Protein GIG1
Mass (kDA):
42.027 kDA
Human | |
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Location: | 1p22.3 |
Sequence: | 1; NC_000001.11 (85580761..85583950) |
Secreted.
This article will examine Boster Bio's CCN1 marker. We'll also talk about high-connectivity DEPs and Mouse monoclonal antibody to CCN1 and the Boster Bio website. Boster's lysis buffers of high-quality will guarantee good results and lower the intensity of cross-linking. Boster Bio has more information. We have summarized the key features and benefits of CCN1 marker and how to use the markers.
The Boster CCN1 Marker has numerous applications that can be utilized in biomedical and biological research. In addition to psoriasis and obliterative bronchiolitis, CCN1 has also been implicated in other autoimmune/inflammatory diseases. CCN1-induced cigarette smoke extract in mice increases IL-8, VEGF and MMP expressions in bronchial epithelial cell cells.
Before, we have explained the role of CCN1 in the liver. CCN1 triggers cell senescence through activating the senescence activated proteins and HSCs. However, it's not clear what role this protein plays in the progression of liver fibrosis. This article will address the mechanism that CCN1 is involved in the process of fibrosis.
FasL, the cellular receptor for cardiac Fas is essential in development and plays a role in cardiotoxicity. However, Fas signaling alone is not sufficient to induce the death of cardiomyocytes in cultured mouse hearts. CCN1 also regulates cell death and promotes various cell-related activities through interaction with distinct Integrin receptors. It is expressed throughout embryogenesis and also in the cardiovascular system. Mice lacking CCN1 die of cardiovascular defects.
We have identified a potential therapeutic target for the anti-CCN1 antibody inside the immune system. Particularly, we examined whether the treatment reduced the number of neutrophils infiltrating tumors, macrophages, and NK cell. By immunostained tumor sections, CD68, HSV-1, and MPO revealed a decrease in CCN1 expression.
The anti-CCN1 antibody is a recombinant, made from rat, mAb that inhibits CCN1 by binding to the epitope of CCN1 mapped to residues 77 to 80 % of the protein. Furthermore, the anti-CCN1 mAb has a high binding affinity to the cyclic peptide, which comprises residues 75-81. It also blocks the growth of FLS and the production of IL-6 from the cells.
In living cells, CCN1 acts through integrin binding sites for a6b1. We have found that CCN1 is delivered via the tail vein, which speeds up the elimination of hepatic dysfunction within the bile drain. We also found that CCN1 is a key player in the regulation and ligation of bile drain.
A study using this antibody has revealed that this monoclonal antibody has the ability to detect CCN1 in the cytoplasm of activated PFs. The antibody was utilized to analyze the activation of activated PFs after treatment with the protein kinase C inhibitor calphostin C or DOX. ImageJ software was used to determine the intensity of each band. It is important to know that CCN1 is an important signal that is involved in the progression of cancer.
Optimisation is essential for high-quality results. Many researchers have issues when conducting experiments. Common problems include excessive background, unanticipated staining and weak fluorescence. Although proper controls can help eliminate a variety of causes of error, there are still some problems that may arise. With this guide, you'll be able to understand how to optimize your Boster Bio experiment. Learn more about optimization and troubleshooting.
PMID: 9135077 by Jay P., et al. The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p.
PMID: 9536281 by Martinerie C., et al. Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system.
*More publications can be found for each product on its corresponding product page