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- Table of Contents
CCR6 Antibodies
AND CCR6 ELISA kits, CCR6 Proteins
Many biological assays use antibodies to detect CCR6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CCR6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CCR6 antibodies...
Designing a Western blot for CCR6? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CCR6 Western Blot GuideCCR6 Infographic by Boster Bio
All CCR6 Products
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CCR6 Overview
Facts about C-C chemokine receptor type 6.
C-C chemokine receptor type 6 (CCR6)
Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036).
Although CCL20 is its major ligand it may also function as a receptor for non-chemokine ligands for example beta-defensins (PubMed:25585877). Binds to defensin DEFB1 resulting in increase in intracellular calcium ions and cAMP levels.
Gene Information
| Human | |
|---|---|
| Gene Name: | CCR6 |
| Uniprot: | P51684 |
| Entrez: | 1235 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
BN-1; CC-CKR-6; CCR6; CCR-6; CD196 antigen; CD196; chemokine (C-C motif) receptor 6; CKRL3; CKR-L3; CKR-L3G-protein coupled receptor 29; CKRL3LARC receptor; CMKBR6; CMKBR6STRL22; DRY6; GPR29; GPR29C-C CKR-6; GPRCY4; GPR-CY4; GPRCY4DRY-6; lymphocyte, 22; STRL22
Molecular Weight
Mass (kDA):
42.494 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q27 |
| Sequence: | 6; NC_000006.12 (167111807..167139141) |
Tissue Specificity
Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cell surface.
Diseases
- Inflammation
- Cholangiocarcinoma
- Neoplasms
- Autoimmune Reaction
- Malignant Neoplasms
- Arthritis
- Autoimmune Diseases
- Rheumatoid Arthritis
- Carcinoma
- Neoplasm Metastasis
- Tissue Adhesions
- Hiv Infections
- Dermatitis
Pathways
- Pathogenesis
- Immune Response
- Chemotaxis
- Secretion
- Localization
- Cell Migration
- Cell Differentiation
- Cytokine Production
- Cell Activation
- Cell Proliferation
- T Cell Activation
- Inflammatory Response
- Cytokine Secretion
PTMs
- Phosphorylation
- Cleavage
- Glycosylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCR6
bosterbio.com/bosterbio-gene-info-cards/CCR6
References
PMID: 9169459 by Baba M., et al. Identification of CCR6, the specific receptor for a novel lymphocyte- directed CC chemokine LARC.
PMID: 8886020 by Zaballos A., et al. Molecular cloning and RNA expression of two new human chemokine receptor-like genes.