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Although CCL20 is its major ligand it may also function as a receptor for non-chemokine ligands for example beta-defensins (PubMed:25585877). Binds to defensin DEFB1 resulting in increase in intracellular calcium ions and cAMP levels.
|G-protein coupled receptor 1 family|
|Sequence:||6; NC_000006.12 (167111807..167139141)|
Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
Cell membrane; Multi-pass membrane protein. Cell surface.