C-C chemokine receptor type 6 (CCR6)

Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036).

Although CCL20 is its major ligand it may also function as a receptor for non-chemokine ligands for example beta-defensins (PubMed:25585877). Binds to defensin DEFB1 resulting in increase in intracellular calcium ions and cAMP levels.