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- Table of Contents
CD3D Antibodies
AND CD3D ELISA kits, CD3D Proteins
Many biological assays use antibodies to detect CD3D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD3D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD3D antibodies...
Designing a Western blot for CD3D? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CD3D Western Blot GuideDesigning an IHC experiment for CD3D? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CD3D IHC GuideCD3D Infographic by Boster Bio
All CD3D Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M04405
100 μl
Cat # M04405
100 μl
CD3D Overview
Facts about T-cell surface glycoprotein CD3 delta chain.
T-cell surface glycoprotein CD3 delta chain (CD3D)
Part of this TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane from the CD3 chains CD3D, CD3E, CD3G and CD3Z.
Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, leading to the activation of downstream signaling pathways (PubMed:2470098). In addition of this function of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation.
Gene Information
| Human | |
|---|---|
| Gene Name: | CD3D |
| Uniprot: | P04234 |
| Entrez: | 915 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD3 antigen, delta subunit; CD3 delta; CD3d antigen; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3D; CD3-DELTA; T3DOKT3, delta chain; T-cell receptor T3 delta chain; T-cell surface glycoprotein CD3 delta chain
Molecular Weight
Mass (kDA):
18.93 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.3 |
| Sequence: | 11; NC_000011.10 (118338954..118342705, complement) |
Tissue Specificity
CD3D is mostly present on T-lymphocytes with its TCR-CD3 partners. Present also in fetal NK-cells.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Leukemia
- Chromosomal Translocation
- Neoplasms
- Malignant Neoplasms
- Acute Lymphocytic Leukemia
- Severe Combined Immunodeficiency
- Myeloid Leukemia
- Paraganglioma
- Dysequilibrium Syndrome
- Head And Neck Neoplasms
- Immunologic Deficiency Syndromes
- Lymphoma
Pathways
- Localization
- Pathogenesis
- Cell Division
- T Cell Differentiation
- Cell Cycle
- Cell Differentiation
- Secretion
- Lymphocyte Activation
- Cell Activation
- Cell Development
- T Cell Activation
- Mitosis
- Aging
PTMs
Research Areas
- Adaptive Immunity
- Apoptosis
- Diabetes Research
- Immunology
- Innate Immunity
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD3D
bosterbio.com/bosterbio-gene-info-cards/CD3D
References
PMID: 2939461 by van den Elsen P., et al. Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex.
PMID: 6095101 by van den Elsen P., et al. Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T- cell receptor complex.
1 Publications of Boster CD3D Antibodies & ELISA Kits
- PubMed ID: 26623936, CD40 Generation 2.5 Antisense Oligonucleotide Treatment Attenuates Doxorubicin-i...
*More publications can be found for each product on its corresponding product page