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- Table of Contents
Membrane cofactor protein Antibodies
AND CD46 ELISA kits, Membrane cofactor protein Proteins
Many biological assays use antibodies to detect Membrane cofactor protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Membrane cofactor protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Membrane cofactor protein antibodies...
Designing a Western blot for Membrane cofactor protein? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CD46 Western Blot GuideCD46 Infographic by Boster Bio
All CD46 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IHC, WB
$370
Cat # M00377-2
100 μg/vial
Cat # M00377-2
100 μg/vial
Human, Rat
IHC, WB
$370
Cat # M00389-2
100 μg/vial
Cat # M00389-2
100 μg/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00377-4
100 μg
Cat # M00377-4
100 μg
CD46 Overview
Facts about Membrane cofactor protein.
Membrane cofactor protein (CD46)
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells from complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the combination of the spermatozoa with the oocyte during fertilization.
Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ to T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
Gene Information
| Human | |
|---|---|
| Gene Name: | CD46 |
| Uniprot: | P15529 |
| Entrez: | 4179 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AHUS2; CD46 antigen; CD46 molecule, complement regulatory protein; CD46; MCP; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MIC10; TLXcomplement regulatory protein; trophoblast leucocyte common antigen; Trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen
Molecular Weight
Mass (kDA):
43.747 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.2 |
| Sequence: | 1; NC_000001.11 (207752038..207795516) |
Tissue Specificity
Expressed by all cells except erythrocytes.
Subcellular Localizations
Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide.
Diseases
- Measles
- Neoplasms
- Malignant Neoplasms
- Hemolytic-uremic Syndrome
- Virus Diseases
- Uremia Syndrome
- Inflammation
- Infective Disorder
- Malignant Paraganglionic Neoplasm
- Carcinoma
- Decreased Immunologic Activity [pe]
- Tissue Adhesions
- Nervousness
Interacting Proteins
- JAG1
Pathways
- Complement Activation
- Pathogenesis
- Immune Response
- Tropism
- Lymphocyte Activation
- Secretion
- Cytolysis
- Localization
- Acrosome Reaction
- Cell Death
- Cell Activation
- Fertilization
- Inflammatory Response
PTMs
- Cleavage
- Glycosylation
- Phosphorylation
- Biotinylation
- Reduction
Research Areas
- Cancer
- Cell Biology
- Cellular Markers
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD46
bosterbio.com/bosterbio-gene-info-cards/CD46
References
PMID: 3260937 by Lublin D.M., et al. Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins.
PMID: 2050389 by Purcell D.F., et al. Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation.