CD48 antigen Antibodies

CD48 antigen (CD48)

Ligand for CD2.

Might facilitate interaction between activated lymphocytes.

Probably involved in regulating T-cell activation. .

Gene Information

Human
Gene Name:	CD48
Uniprot:	P09326
Entrez:	962

Family

Belongs to:
No superfamily

Alternative Names

BCM1 surface antigen; BCM1; BCM1Leukocyte antigen MEM-102; BLAST; BLAST1; BLAST1TCT.1; B-lymphocyte activation marker BLAST-1; CD48 antigen (B-cell membrane protein); CD48 antigen; CD48 molecule; CD48; hCD48; mCD48; MEM-102; SLAMF2

Molecular Weight

Mass (kDA):
27.683 kDA

Genomic Context

Human
Location:	1q23.3
Sequence:	1; NC_000001.11 (160678746..160711851, complement)

Subcellular Localizations

Cell membrane; Lipid-anchor, GPI-anchor.

Diseases

• Tissue Adhesions
• Neoplasms
• X-linked Lymphoproliferative Disorders
• Lymphoproliferative Disorders
• Paroxysmal Nocturnal Hemoglobinuria
• Hemoglobinuria
• Hemoglobinuria, Paroxysmal
• Anemia
• Malignant Neoplasms
• Infective Disorder
• Aplastic Anemia
• Lymphoma
• Autoimmune Reaction

• Leukemia
• Immunologic Deficiency Syndromes
• Melanoma
• Melanoma, Experimental
• Asthma
• Virus Diseases
• Diabetes Mellitus

Interacting Proteins

• CD244

Pathways

• Cell Activation
• T Cell Activation
• Lymphocyte Activation
• Cell Adhesion
• Immune Response
• Secretion
• Cell Proliferation
• Localization
• Cell Cycle
• Glycosylation
• Pathogenesis
• T Cell Proliferation
• Cytokine Production

• Leukocyte Activation
• Cell Recognition
• Cell-cell Adhesion
• Cytolysis
• Cytokine Secretion
• Inflammatory Response
• Cell Killing

PTMs

• Phosphorylation
• Glycosylation
• Acylation
• Gpi Anchoring

• Deglycosylation
• Cleavage
• Methylation
• Palmitoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD48

Boster Bio: Best Uses Of The CD48 Marker

This article will provide you with some details on Boster Bio: The best uses for the Cell Death Antibody. The article will also address the Hashtag Reagents and the Classification tree built on 10 biomarkers that can be used to predict of immune clusters that evade. Boster Bio optimization tips will be explained. Continue reading to find out more. Don't forget to tell us your experiences!

Boster Bio Anti-CD48 Antibody

Boster Bio Anti CD48 Antibody is monoclonal antibody that reacts with Human cells' CD48 marker. It can be tested in WB and IP as well as IHC. The antibody can be stored at -20°C and frozen for 6 months. This product is designed for WB applications and has been tested against Human and mouse cells. You can also purchase blocking peptides, and test on other samples to verify that the Boster Bio Anti-CD48 antibody is working as it should be.

Studies have shown that CD48 enhances the activation and the tolerance of T cells. CD48mice have defects in antigen-specific tolerance in the vivo. However, the underlying mechanism isn't fully understood. However, studies have shown increased expression of CD58 in Tregs and is linked to remission of MS. (MS). Other studies suggest that CD48 might interact with different binding partners on various cells.

Although CD48 is a significant marker for T cells however the mechanism through that it hinders T cell activation and proliferation is not clear. It is believed that CD48 has a role in limiting the capacity of NK and CTL cells to lyse target cells. However, more research is needed to determine its specific functions. Additionally, combination therapies that target the CD48 marker could be extremely beneficial.

It is crucial to use the right tools to study the functions of CD48 due to its high level of expression. The CD48 marker is found on a variety of hematopoietic cell types and is upregulated in certain subsets. CD48 also plays an antigen-presenting role in the immune system and interacts with CD244 and NK cells. These interactions may differ depending on the state of the immune response.

CD48, which is the anti-receptor for CD244 on N cells, can influence B cell responses to antigens derived from T. Anti-CD48 mAb treatment has been demonstrated to increase the production of IgG1 as well as IgG2a in B6 mouse models, which suggests that this antibody may be able to influence B cell responses to T cell-dependent antigens.

Boster Bio Hashtag Reagents

Boster Bio Hashtag Reagent for CD48 is an extremely specific antibody designed for barcoding samples, demultiplexing during analysis and covering the broadest range of cells. Human hashtags are comprised of two antibodies that recognize common surface markers (CD45 and H-2 MHC class I) The mouse hashtags utilize one antibody that recognizes CD45 and H-2 MHC class I.

Classification tree containing 10 biomarkers that can predict of immune clusters of evasion

A Classification tree comprising 10 biomarkers that are predictive of immune evasion . It identifies three kinds of clusters. Each cluster is made up of subsets of ten ARGs. Each of these mRNAs have specific functions. The ARGs included in the analysis are those involved with lymphocyte activation as well as the adaptive immune response and the signaling pathway that is mediated by cytokine.

The results indicated that CD8A and GZMB, as well as CXCL9, CXCL10, were expressed more often in cluster A than they are in cluster B. The expression levels of PRF1 and TBX21 were also increased in cluster A. Cluster A also had a higher ssGSEA value that measures the infiltration of 24 immune cell in the TIM.

The median risk coefficient in the analysis identifies patients with high and low risk. Other risk factors included in the model include grade, lymphatic invasion, and staging. The biomarker's hazard rate (HR), allows for the differentiation between risk and protective genes. These markers are crucial in diagnosing patients suffering from RA. These markers can be used to classify patients or to determine their prognosis.

Boster Bio optimization tips

If you're using Boster Bio antibodies for CD48 staining, isotype controls or detection systems that are optimized for IHC You'll be able to find the right antibody for your research. Boster Bio offers guides and protocols that explain the various options and address common questions. Find out more about Boster Bio products by checking out their datasheets. This article will go over the various options and how to use them.