Lymphocyte function-associated antigen 3 (CD58)

Ligand of the T-lymphocyte CD2 glycoprotein.

This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen- presenting cells and the T-lymphocyte rosetting with erythrocytes.

In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. .